EPB41L3 Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N-methyltransferases, including PRMT3 and PRMT5. Expressed at high levels in brain, with lower levels in kidney, intestine, and testis. Detected in lung. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis; Tumor suppressor
Chromosomal Location of Human Ortholog: 18p11.31
Cellular Component:  cell-cell junction; cytoskeleton; cytosol; juxtaparanode region of axon; paranode region of axon; plasma membrane; postsynaptic density
Molecular Function:  actin binding; protein binding; structural constituent of cytoskeleton
Biological Process:  apoptotic process; cortical actin cytoskeleton organization; cortical cytoskeleton organization; cytoskeletal anchoring at plasma membrane; myelin maintenance; neuron projection morphogenesis; paranodal junction assembly; protein localization to juxtaparanode region of axon; protein localization to paranode region of axon; protein localization to plasma membrane; regulation of cell growth; regulation of cell shape
Reference #:  Q9Y2J2 (UniProtKB)
Alt. Names/Synonyms: 4.1B; Band 4.1-like protein 3; Band 4.1-like protein 3, N-terminally processed; DAL-1; DAL1; Differentially expressed in adenocarcinoma of the lung protein 1; E41L3; EPB41L3; erythrocyte membrane protein band 4.1 like 3; erythrocyte membrane protein band 4.1-like 3; FLJ37633; KIAA0987
Gene Symbols: EPB41L3
Molecular weight: 120,678 Da
Basal Isoelectric point: 5.09  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB