talin 1 Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 9p13.3
Cellular Component:  cell surface; cytoskeleton; cytosol; extracellular region; focal adhesion; ruffle; ruffle membrane
Molecular Function:  actin filament binding; integrin binding; LIM domain binding; phosphatidylinositol binding; phosphatidylserine binding; protein binding; structural constituent of cytoskeleton; vinculin binding
Biological Process:  cell-cell junction assembly; cell-substrate junction assembly; cortical actin cytoskeleton organization; cytoskeletal anchoring at plasma membrane; integrin activation; integrin-mediated signaling pathway; IRE1-mediated unfolded protein response; muscle contraction; platelet degranulation; viral process
Reference #:  Q9Y490 (UniProtKB)
Alt. Names/Synonyms: ILWEQ; KIAA1027; talin 1; Talin-1; talin1; TLN; TLN1
Gene Symbols: TLN1
Molecular weight: 269,767 Da
Basal Isoelectric point: 5.77  Predict pI for various phosphorylation states
CST Pathways:  Growth And Differentiation Control by MAPKs  |  T Cell Receptor Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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talin 1

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  CCLE  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene