talin 1 a cytoskeletal protein which is concentrated in areas of cell-substratum and cell-cell contacts. This protein plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to other cells. The N-terminus of this protein contains elements for localization to cell-extracellular matrix junctions. The C-terminus contains binding sites for proteins such as beta-1-integrin, actin, and vinculin. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 9p13.3
Cellular Component:  cell surface; cytoskeleton; cytosol; extracellular region; focal adhesion; ruffle; ruffle membrane
Molecular Function:  actin filament binding; integrin binding; LIM domain binding; phosphatidylinositol binding; phosphatidylserine binding; protein binding; structural constituent of cytoskeleton; vinculin binding
Biological Process:  cell-cell junction assembly; cell-substrate junction assembly; cortical actin cytoskeleton organization; cytoskeletal anchoring at plasma membrane; integrin activation; integrin-mediated signaling pathway; IRE1-mediated unfolded protein response; muscle contraction; platelet degranulation; viral process
Reference #:  Q9Y490 (UniProtKB)
Alt. Names/Synonyms: KIAA1027; talin 1; Talin-1; talin1; TLN; TLN1
Gene Symbols: TLN1
Molecular weight: 269,767 Da
Basal Isoelectric point: 5.77  Predict pI for various phosphorylation states
CST Pathways:  Growth And Differentiation Control by MAPKs  |  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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talin 1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  CCLE  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene