SNX1 Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity. Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptors (IGF2R, M6PR and SORT1) and Shiginella dysenteria toxin stxB. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi. Involvement in retromer-independent endocytic trafficking of P2RY1 and lysosomal degradation of protease-activated receptor-1/F2R. Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN. Required for endocytosis of DRD5 upon agonist stimulation but not for basal receptor trafficking. Belongs to the sorting nexin family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Vesicle
Chromosomal Location of Human Ortholog: 15q22.31
Cellular Component:  cytoplasm; cytosol; early endosome membrane; endosome; endosome membrane; Golgi apparatus; intracellular membrane-bounded organelle; lamellipodium; lysosome; membrane; protein-containing complex; retromer complex; retromer, tubulation complex; vesicle
Molecular Function:  epidermal growth factor receptor binding; identical protein binding; insulin receptor binding; leptin receptor binding; phosphatidylinositol binding; protein binding; protein heterodimerization activity; protein homodimerization activity; transferrin receptor binding
Biological Process:  early endosome to Golgi transport; intracellular protein transport; lamellipodium morphogenesis; positive regulation of protein catabolic process; receptor internalization; retrograde transport, endosome to Golgi
Reference #:  Q13596 (UniProtKB)
Alt. Names/Synonyms: HsT17379; MGC8664; SNX1; SNX1A; sorting nexin 1; sorting nexin 1A; Sorting nexin-1; Vps5
Gene Symbols: SNX1
Molecular weight: 59,070 Da
Basal Isoelectric point: 5.08  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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