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G-alpha(q)
Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro). Belongs to the G-alpha family. G(q) subfamily. Predominantly expressed in ovary, prostate, testis and colon. Down-regulated in the peripheral blood lymphocytes (PBLs) of rheumatoid arthritis patients (at protein level). Note: This description may include information from UniProtKB.
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| Protein type: G protein; G protein, heterotrimeric; G protein, heterotrimeric alpha G(q) |
| Chromosomal Location of Human Ortholog: 9q21.2 |
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Cellular Component:
cytoplasm; nuclear membrane; photoreceptor outer segment; plasma membrane
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Molecular Function:
GTP binding; GTPase activator activity; metal ion binding; protein binding
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Biological Process:
activation of phospholipase C activity; blood coagulation; entrainment of circadian clock; G protein-coupled acetylcholine receptor signaling pathway; G protein-coupled receptor signaling pathway; negative regulation of protein kinase activity; phototransduction, visible light; platelet activation; positive regulation of GTPase activity; protein stabilization; regulation of canonical Wnt signaling pathway
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Disease: Capillary Malformations, Congenital; Sturge-weber Syndrome
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Reference #:
P50148
(UniProtKB)
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Alt. Names/Synonyms: CMC1; epididymis secretory sperm binding protein; G protein subunit alpha q; G-alpha(q); G-ALPHA-q; GAQ; GNAQ; guanine nucleotide binding protein (G protein), q polypeptide; Guanine nucleotide-binding protein alpha-q; Guanine nucleotide-binding protein G(q) subunit alpha; SWS
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Gene Symbols: GNAQ
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Molecular weight:
42,142 Da
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Basal Isoelectric point:
5.48
Predict pI for various phosphorylation states
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CST Pathways:
Actin Dynamics
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AMPK Signaling
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ESC Pluripotency and Differentiation
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GPCR Signaling to MAPKs
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Microtubule Dynamics
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mTOR Signaling
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Phospholipase Signaling
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PI3K/Akt Signaling
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Translation: eIF4E and p70S6K
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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