| G-alpha(q) Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro). Belongs to the G-alpha family. G(q) subfamily. Predominantly expressed in ovary, prostate, testis and colon. Down-regulated in the peripheral blood lymphocytes (PBLs) of rheumatoid arthritis patients (at protein level). Note: This description may include information from UniProtKB. |
| Protein type: G protein; G protein, heterotrimeric; G protein, heterotrimeric alpha G(q) |
| Chromosomal Location of human Ortholog: 9q21.2 |
| Cellular Component: cytoplasm; Golgi apparatus; heterotrimeric G-protein complex; nuclear membrane; photoreceptor outer segment; plasma membrane; synapse |
| Molecular Function: G protein-coupled receptor binding; G-protein beta/gamma-subunit complex binding; GTP binding; GTPase activator activity; GTPase activity; metal ion binding; protein binding |
| Biological Process: action potential; activation of phospholipase C activity; adenylate cyclase-activating G protein-coupled receptor signaling pathway; blood coagulation; entrainment of circadian clock; G protein-coupled acetylcholine receptor signaling pathway; glutamate receptor signaling pathway; negative regulation of protein kinase activity; phospholipase C-activating dopamine receptor signaling pathway; phototransduction, visible light; protein stabilization; regulation of canonical Wnt signaling pathway; regulation of platelet activation |
| Disease: Capillary Malformations, Congenital; Sturge-weber Syndrome |
| Reference #: P50148 (UniProtKB) |
| Alt. Names/Synonyms: CMC1; epididymis secretory sperm binding protein; G protein subunit alpha q; G-alpha(q); G-ALPHA-q; GAQ; GNAQ; guanine nucleotide binding protein (G protein), q polypeptide; Guanine nucleotide-binding protein alpha-q; Guanine nucleotide-binding protein G(q) subunit alpha; SWS |
| Gene Symbols: GNAQ |
| Molecular weight: 42,142 Da |
| Basal Isoelectric point: 5.48 Predict pI for various phosphorylation states |
| CST Pathways: Actin Dynamics | AMPK Signaling | ESC Pluripotency and Differentiation | GPCR Signaling to MAPKs | Microtubule Dynamics | mTOR Signaling | Phospholipase Signaling | PI3K/Akt Signaling | Translation: eIF4E and p70S6K |
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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G-alpha(q) |
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Cross-references to other databases:
AlphaFold
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STRING
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cBioPortal
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Wikipedia
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Reactome
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neXtProt
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Protein Atlas
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BioGPS
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Pfam
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