G-alpha(q) Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro). Belongs to the G-alpha family. G(q) subfamily. Predominantly expressed in ovary, prostate, testis and colon. Down-regulated in the peripheral blood lymphocytes (PBLs) of rheumatoid arthritis patients (at protein level). Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, heterotrimeric; G protein, heterotrimeric alpha G(q)
Chromosomal Location of Human Ortholog: 19 A|19 11.01 cM
Cellular Component:  caveola; cell body; cytosol; dendrite; heterotrimeric G-protein complex; membrane; nucleus; plasma membrane; protein-containing complex
Molecular Function:  alkylglycerophosphoethanolamine phosphodiesterase activity; G protein-coupled receptor binding; G-protein beta/gamma-subunit complex binding; GTP binding; GTPase activator activity; GTPase activity; guanyl nucleotide binding; metal ion binding; nucleotide binding; protein binding; protein-containing complex binding; type 2A serotonin receptor binding
Biological Process:  action potential; activation of phospholipase C activity; adenylate cyclase-activating G protein-coupled receptor signaling pathway; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; developmental pigmentation; embryonic digit morphogenesis; forebrain neuron development; G protein-coupled receptor signaling pathway; glutamate receptor signaling pathway; heart development; maternal behavior; negative regulation of apoptotic process; negative regulation of potassium ion transport; negative regulation of protein kinase activity; neuron remodeling; phospholipase C-activating dopamine receptor signaling pathway; phospholipase C-activating G protein-coupled receptor signaling pathway; positive regulation of smooth muscle cell proliferation; post-embryonic development; protein heterotrimerization; protein stabilization; regulation of canonical Wnt signaling pathway; regulation of melanocyte differentiation; signal transduction; skeletal system development
Reference #:  P21279 (UniProtKB)
Alt. Names/Synonyms: 1110005L02Rik; 6230401I02Rik; AA408290; AW060788; Dsk; Dsk1; Dsk10; G alpha q; G-alpha(q); Gal; Galphaq; Gnaq; Gq; GqI; guanine nucleotide binding protein, alpha q polypeptide; Guanine nucleotide-binding protein alpha-q; Guanine nucleotide-binding protein G(q) subunit alpha
Gene Symbols: Gnaq
Molecular weight: 42,158 Da
Basal Isoelectric point: 5.48  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  AMPK Signaling  |  ESC Pluripotency and Differentiation  |  GPCR Signaling to MAPKs  |  Microtubule Dynamics  |  mTOR Signaling  |  Phospholipase Signaling  |  PI3K/Akt Signaling  |  Translation: eIF4E and p70S6K
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene