PRKRIR Upstream regulator of interferon-induced serine/threonine protein kinase R (PKR). May block the PKR-inhibitory function of DNAJC3, resulting in restoration of kinase activity and suppression of cell growth. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Protein kinase, regulatory subunit
Chromosomal Location of Human Ortholog: 11q13.5
Cellular Component:  nucleus
Molecular Function:  DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; metal ion binding; protein binding; protein dimerization activity
Biological Process:  negative regulation of cell proliferation; regulation of transcription by RNA polymerase II; signal transduction
Reference #:  O43422 (UniProtKB)
Alt. Names/Synonyms: 52 kDa repressor of the inhibitor of the protein kinase; 58 kDa interferon-induced protein kinase-interacting protein; DAP4; Death-associated protein 4; inhibitor of protein kinase PKR; MGC102750; P52K; P52RIPK; p58IPK-interacting protein; P58IPK-regulatory protein; PRKRIR; protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor); testicular tissue protein Li 133; THAP domain containing 12; THAP domain-containing protein 0; THAP domain-containing protein 12; THAP0; THAP12
Gene Symbols: THAP12
Molecular weight: 87,704 Da
Basal Isoelectric point: 5.58  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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