NuMA-1 a microtubule (MT)-binding protein that plays a role in the formation and maintenance of the spindle poles and the alignment and segregation of chromosomes during mitotic cell division. Functions to tether the minus ends of MTs at the spindle poles, which is critical for the establishment and maintenance of the spindle poles. Plays a role in the establishment of the mitotic spindle orientation during metaphase and elongation during anaphase in a dynein-dynactin-dependent manner. In metaphase, part of a ternary complex composed of GPSM2 and G(i) alpha proteins, that regulates the recruitment and anchorage of the dynein-dynactin complex in the mitotic cell cortex regions situated above the two spindle poles, and hence regulates the correct orientation of the mitotic spindle. During anaphase, mediates the recruitment and accumulation of the dynein-dynactin complex at the cell membrane of the polar cortical region through direct association with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), and hence participates in the regulation of the spindle elongation and chromosome segregation. Binds also to other polyanionic phosphoinositides, such as phosphatidylinositol 3-phosphate (PIP), lysophosphatidic acid (LPA) and phosphatidylinositol triphosphate (PIP3), in vitro. Plays a role in mitotic MT aster assembly. Involved in anastral spindle assembly. Positively regulates TNKS protein localization to spindle poles in mitosis. Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority of the nuclear volume. Dissociates from condensing chromosomes during early prophase, before the complete disintegration of the nuclear lamina. As mitosis progresses it reassociates with telophase chromosomes very early during nuclear reformation, before substantial accumulation of lamins on chromosomal surfaces is evident. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 7|7 E2
Cellular Component:  apical part of cell; cell cortex; cell cortex region; centrosome; chromosome; cortical microtubule; cytoplasm; cytoplasmic microtubule bundle; cytoskeleton; cytosol; dendrite; extrinsic component of plasma membrane; Golgi membrane; lateral cell cortex; membrane; microtubule; microtubule bundle; microtubule minus-end; microtubule plus-end; mitotic spindle; mitotic spindle astral microtubule; mitotic spindle midzone; mitotic spindle pole; neuronal cell body; nuclear matrix; nucleoplasm; nucleus; plasma membrane; protein-containing complex; spindle microtubule; spindle pole; spindle pole centrosome
Molecular Function:  disordered domain specific binding; dynein complex binding; lipid binding; microtubule binding; microtubule minus-end binding; microtubule plus-end binding; phosphatidylinositol binding; protein C-terminus binding; protein domain specific binding; protein-containing complex binding; tubulin binding
Biological Process:  anastral spindle assembly; astral microtubule organization; cell cycle; cell division; chromosome segregation; establishment of mitotic spindle orientation; lung epithelial cell differentiation; microtubule bundle formation; positive regulation of BMP signaling pathway; positive regulation of chromosome segregation; positive regulation of chromosome separation; positive regulation of hair follicle development; positive regulation of intracellular transport; positive regulation of keratinocyte differentiation; positive regulation of microtubule polymerization; positive regulation of mitotic spindle elongation; positive regulation of protein localization to cell cortex; positive regulation of protein localization to spindle pole body; positive regulation of spindle assembly; regulation of metaphase plate congression; regulation of mitotic spindle organization
Reference #:  E9Q7G0 (UniProtKB)
Alt. Names/Synonyms: 6720401E04Rik; AA764025; AL022610; AU014979; Nuclear mitotic apparatus protein; Nuclear mitotic apparatus protein 1; NuMA; NuMA protein; NuMA-1; Numa1
Gene Symbols: Numa1
Molecular weight: 235,658 Da
Basal Isoelectric point: 5.68  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein