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Plectin-1
Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. Belongs to the plakin or cytolinker family. Widely expressed with highest levels in muscle, heart, placenta and spinal cord. 9 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cytoskeletal; Motility/polarity/chemotaxis |
| Chromosomal Location of mouse Ortholog: 15 D3|15 35.48 cM |
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Cellular Component:
anchoring junction; apical plasma membrane; axon; basal plasma membrane; brush border; cell periphery; contractile fiber; cytoplasm; cytoskeleton; cytosol; dendrite; focal adhesion; hemidesmosome; intermediate filament; intermediate filament cytoskeleton; mitochondrial outer membrane; myelin sheath; myofibril; perinuclear region of cytoplasm; sarcolemma; sarcoplasm; Z disc
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Molecular Function:
actin binding; actin filament binding; ankyrin binding; cytoskeletal protein binding; dystroglycan binding; protein binding; protein self-association; structural constituent of cytoskeleton; structural constituent of muscle
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Biological Process:
actin cytoskeleton organization; actin filament organization; actomyosin contractile ring assembly actin filament organization; adherens junction organization; cardiac muscle cell development; cell morphogenesis; cell motility; cellular response to extracellular stimulus; cellular response to fluid shear stress; cellular response to hydrostatic pressure; cellular response to mechanical stimulus; establishment of skin barrier; fibroblast migration; gene expression; hemidesmosome assembly; intermediate filament cytoskeleton organization; intermediate filament organization; keratinocyte development; keratinocyte differentiation; leukocyte migration involved in immune response; mitochondrion morphogenesis; mitochondrion organization; multicellular organism growth; myelination in peripheral nervous system; myoblast differentiation; negative regulation of protein kinase activity; nucleus organization; peripheral nervous system myelin maintenance; protein localization; protein-containing complex organization; regulation of ATP citrate synthase activity; regulation of vascular permeability; respiratory electron transport chain; response to food; response to nutrient; sarcomere organization; skeletal muscle fiber development; skeletal muscle tissue development; skeletal myofibril assembly; skin development; T cell chemotaxis; tight junction organization; transmission of nerve impulse; wound healing
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Reference #:
Q9QXS1
(UniProtKB)
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Alt. Names/Synonyms: AA591047; AU042537; EBS1; PCN; Ple; Plec; Plec1; Plectin; plectin 1; Plectin-1; Plectin-6; PLTN
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Gene Symbols: Plec
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Molecular weight:
534,188 Da
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Basal Isoelectric point:
5.74
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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