EHD4 ATP- and membrane-binding protein that probably controls membrane reorganization/tubulation upon ATP hydrolysis. Plays a role in early endosomal transport. Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. EHD subfamily. Highly expressed in pancreas and heart. Note: This description may include information from UniProtKB.
Protein type: Extracellular matrix
Chromosomal Location of mouse Ortholog: 2|2 E5
Cellular Component:  endoplasmic reticulum; endosome; membrane; perinuclear region of cytoplasm; plasma membrane; recycling endosome membrane
Molecular Function:  ATP binding; calcium ion binding; GTP binding; metal ion binding; nucleotide binding; protein binding
Biological Process:  cellular response to growth factor stimulus; endocytic recycling; pinocytosis; positive regulation of peptidyl-tyrosine phosphorylation; protein homooligomerization; regulation of endocytosis
Reference #:  Q9EQP2 (UniProtKB)
Alt. Names/Synonyms: 2210022F10Rik; AI197390; AI846352; AV006278; EH domain containing protein MPAST2; EH domain-containing protein 4; EH-domain containing 4; Ehd4; mPAST2; OTTMUSP00000016279; PAST homolog 2; Past2
Gene Symbols: Ehd4
Molecular weight: 61,481 Da
Basal Isoelectric point: 6.33  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein