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CTSK
Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Belongs to the peptidase C1 family. Predominantly expressed in osteoclasts (bones). Note: This description may include information from UniProtKB.
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| Protein type: EC 3.4.22.38; Protease |
| Chromosomal Location of Human Ortholog: 3 F2.1|3 40.74 cM |
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Cellular Component:
cytoplasm; extracellular space; intracellular membrane-bounded organelle; lysosome; nucleoplasm
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Molecular Function:
collagen binding; cysteine-type endopeptidase activity; cysteine-type peptidase activity; fibronectin binding; hydrolase activity; peptidase activity; proteoglycan binding
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Biological Process:
bone resorption; collagen catabolic process; negative regulation of cartilage development; proteolysis; proteolysis involved in cellular protein catabolic process
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Reference #:
P55097
(UniProtKB)
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Alt. Names/Synonyms: AI323530; cat; Cat K; Cathepsin K; catK; Ctsk; minisatellite 10q detected by probe MMS10; MMS10-Q; Ms10q
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Gene Symbols: Ctsk
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Molecular weight:
36,889 Da
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Basal Isoelectric point:
8.61
Predict pI for various phosphorylation states
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