CTSK Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Belongs to the peptidase C1 family. Predominantly expressed in osteoclasts (bones). Note: This description may include information from UniProtKB.
Protein type: EC; Protease
Chromosomal Location of mouse Ortholog: 3 F2.1|3 40.74 cM
Cellular Component:  cytoplasm; extracellular space; intracellular membrane-bounded organelle; lysosome; nucleoplasm
Molecular Function:  collagen binding; cysteine-type endopeptidase activity; cysteine-type peptidase activity; fibronectin binding; hydrolase activity; peptidase activity; proteoglycan binding
Biological Process:  bone resorption; collagen catabolic process; negative regulation of cartilage development; proteolysis; proteolysis involved in cellular protein catabolic process
Reference #:  P55097 (UniProtKB)
Alt. Names/Synonyms: AI323530; cat; Cat K; Cathepsin K; catK; Ctsk; minisatellite 10q detected by probe MMS10; MMS10-Q; Ms10q
Gene Symbols: Ctsk
Molecular weight: 36,889 Da
Basal Isoelectric point: 8.61  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene