anillin Required for cytokinesis. Essential for the structural integrity of the cleavage furrow and for completion of cleavage furrow ingression. Plays a role in bleb assembly during metaphase and anaphase of mitosis. May play a significant role in podocyte cell migration. Ubiquitously expressed. Present at highest levels in the brain, at high levels in the placenta and testis, at intermediate levels in the intestine, ovary, skeletal muscle and thymus and at lower levels in heart, kidney, liver, lung, pancreas, prostate and spleen. In the kidney, it is widely expressed in tubules, but sparsely expressed in the glomerulus (PubMed:24676636). Expression is significantly increased in renal biopsy specimens from idiopathic FSGS (PubMed:24676636). Overexpressed in many tumor types including breast, colorectal, endometrial, hepatic, kidney, lung, ovarian and pancreatic tumors. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Actin-binding; Motility/polarity/chemotaxis
Chromosomal Location of mouse Ortholog: 9|9 A3
Cellular Component:  actin cytoskeleton; actomyosin contractile ring; bleb; cell cortex region; cell projection; cytoplasm; cytoskeleton; midbody; nucleoplasm; nucleus
Molecular Function:  actin binding; GTP-Rho binding
Biological Process:  actomyosin contractile ring assembly; cell cycle; cell division; cortical cytoskeleton organization; glomerular visceral epithelial cell migration; hematopoietic progenitor cell differentiation; mitotic cytokinesis; positive regulation of bleb assembly; protein localization to mitotic actomyosin contractile ring; septin ring organization
Reference #:  Q8K298 (UniProtKB)
Alt. Names/Synonyms: 1110037A17Rik; 2900037I21Rik; Actin-binding protein anillin; Anillin; anillin, actin binding protein; anillin, actin binding protein (scraps homolog, Drosophila); Anln; C78101; Scraps
Gene Symbols: Anln
Molecular weight: 122,794 Da
Basal Isoelectric point: 6.59  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene