SMG9 Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG8 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required for the efficient association between SMG1 and SMG8. Plays a role in brain, heart, and eye development. Belongs to the SMG9 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA processing
Chromosomal Location of Human Ortholog: 7|7 A3
Cellular Component: 
Molecular Function:  identical protein binding
Biological Process:  brain development; eye development; heart development; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
Reference #:  Q9DB90 (UniProtKB)
Alt. Names/Synonyms: 1500002O20Rik; AI429693; N2809; N28092; OTTMUSP00000025208; Protein smg-9 homolog; Protein SMG9; RIKEN cDNA 1500002O20 gene; smg-9 homolog, nonsense mediated mRNA decay factor (C. elegans); Smg9
Gene Symbols: Smg9
Molecular weight: 57,621 Da
Basal Isoelectric point: 6.52  Predict pI for various phosphorylation states
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SMG9

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene