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REEP4
Microtubule-binding protein required to ensure proper cell division and nuclear envelope reassembly by sequestering the endoplasmic reticulum away from chromosomes during mitosis. Probably acts by clearing the endoplasmic reticulum membrane from metaphase chromosomes. Belongs to the DP1 family. Expressed in circumvallate papillae and testis. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral; Membrane protein, multi-pass |
| Chromosomal Location of mouse Ortholog: 14|14 D2 |
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Cellular Component:
cytoplasmic microtubule; endoplasmic reticulum; endoplasmic reticulum membrane; endoplasmic reticulum tubular network; membrane; microtubule
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Molecular Function:
microtubule binding
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Biological Process:
cell cycle; cell division; endoplasmic reticulum tubular network organization; mitotic nuclear membrane reassembly; nuclear envelope organization
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Reference #:
Q8K072
(UniProtKB)
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Alt. Names/Synonyms: 2700029E10Rik; receptor accessory protein 4; receptor expression enhancing protein 4; Receptor expression-enhancing protein 4; Reep4
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Gene Symbols: Reep4
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Molecular weight:
29,691 Da
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Basal Isoelectric point:
9.8
Predict pI for various phosphorylation states
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