CDC25C iso3 Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. When phosphorylated, highly effective in activating G2 cells into prophase. Directly dephosphorylates CDK1 and activates its kinase activity. Belongs to the MPI phosphatase family. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity
Chromosomal Location of Human Ortholog: 5q31.2
Cellular Component:  cytosol; nuclear speck; nucleoplasm; nucleus; perinuclear region of cytoplasm
Molecular Function:  protein binding; protein kinase binding; protein tyrosine phosphatase activity; WW domain binding
Biological Process:  cell division; cell proliferation; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; G2/M transition of mitotic cell cycle; peptidyl-tyrosine dephosphorylation; regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of mitotic nuclear division; spermatogenesis; viral process
Reference #:  P30307-3 (UniProtKB)
Alt. Names/Synonyms: CDC25; CDC25C; CDC25C iso3; cell division cycle 25 homolog C (S. pombe); cell division cycle 25C; Dual specificity phosphatase Cdc25C; M-phase inducer phosphatase 3; mitosis inducer CDC25; MPIP3; phosphotyrosine phosphatase; PPP1R60; protein phosphatase 1, regulatory subunit 60
Gene Symbols: CDC25C
Molecular weight: 48,851 Da
Basal Isoelectric point: 7.48  Predict pI for various phosphorylation states
CST Pathways:  G2/M DNA Damage Checkpoint  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs
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CDC25C iso3

Protein Structure Not Found.


Cross-references to other databases:  cBioPortal  |  Wikipedia  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene