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PAI-RBP1
May play a role in the regulation of mRNA stability. Binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay. Seems to play a role in PML-nuclear bodies formation. Expressed at high level in the heart, skeletal muscle and kidney, and at low levels in placenta, liver and brain. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: RNA-binding |
| Chromosomal Location of mouse Ortholog: 6|6 C1 |
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Cellular Component:
cytoplasm; cytosol; nucleus
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Molecular Function:
mRNA 3'-UTR binding; ribosome binding; RNA binding; SUMO binding; translation elongation factor binding; translation repressor activity
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Biological Process:
negative regulation of translation; PML body organization; regulation of apoptotic process; ribosome hibernation
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Reference #:
Q9CY58
(UniProtKB)
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Alt. Names/Synonyms: 1200009K13Rik; 9330147J08Rik; AL022786; PAI-1 mRNA-binding protein; PAI-RBP1; PAI1 RNA-binding protein 1; PAIRB; Pairbp1; Plasminogen activator inhibitor 1 RNA-binding protein; Serbp1; serpine1 mRNA binding protein 1; SERPINE1 mRNA-binding protein 1
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Gene Symbols: Serbp1
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Molecular weight:
44,714 Da
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Basal Isoelectric point:
8.6
Predict pI for various phosphorylation states
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