PAI-RBP1 May play a role in the regulation of mRNA stability. Binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay. Seems to play a role in PML-nuclear bodies formation. Expressed at high level in the heart, skeletal muscle and kidney, and at low levels in placenta, liver and brain. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA-binding
Chromosomal Location of Human Ortholog: 6|6 C1
Cellular Component:  cytoplasm; cytosol; nucleus
Molecular Function:  mRNA 3'-UTR binding; RNA binding; SUMO binding
Biological Process:  PML body organization
Reference #:  Q9CY58 (UniProtKB)
Alt. Names/Synonyms: 1200009K13Rik; 9330147J08Rik; AL022786; PAI-1 mRNA-binding protein; PAI-RBP1; PAI1 RNA-binding protein 1; PAIRB; Pairbp1; Plasminogen activator inhibitor 1 RNA-binding protein; Serbp1; serpine1 mRNA binding protein 1; SERPINE1 mRNA-binding protein 1
Gene Symbols: Serbp1
Molecular weight: 44,714 Da
Basal Isoelectric point: 8.6  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene