LAB Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2. Highly expressed in spleen, peripheral blood lymphocytes, and germinal centers of lymph nodes. Also expressed in placenta, lung, pancreas and small intestine. Present in B-cells, NK cells and monocytes. Absent from T-cells (at protein level). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Membrane protein, integral
Chromosomal Location of Human Ortholog: 5|5 G2
Cellular Component:  integral component of membrane; membrane; membrane raft; plasma membrane
Molecular Function:  SH2 domain binding
Biological Process:  adaptive immune response; B cell activation; B cell receptor signaling pathway; calcium-mediated signaling; immune response-regulating signaling pathway; immune system process; intracellular signal transduction; mast cell degranulation
Reference #:  Q9JHL0 (UniProtKB)
Alt. Names/Synonyms: AW125574; Lab; Lat2; Linker for activation of B-cells; linker for activation of T cells family, member 2; Linker for activation of T-cells family member 2; Membrane-associated adapter molecule; non-T cell activation linker; Non-T-cell activation linker; Ntal; Wbscr15; Wbscr5; Williams-Beuren syndrome chromosomal region 15 protein homolog; Williams-Beuren syndrome chromosome region 15 homolog; Williams-Beuren syndrome chromosome region 5 homolog; WSCR5
Gene Symbols: Lat2
Molecular weight: 22,876 Da
Basal Isoelectric point: 4.73  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene