LAB linker for activation of B cells (LAB) is an adaptor protein. B cell antigen receptor signaling leads to its phosphorylation and interaction with the adaptor protein Grb2. Decreased expression leads to a reduction in BCR-mediated calcium flux and Erk activation. Localized to lipid rafts. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Membrane protein, integral
Chromosomal Location of Human Ortholog: 5|5 G2
Cellular Component:  integral component of membrane; membrane; membrane raft; plasma membrane
Molecular Function:  SH2 domain binding
Biological Process:  adaptive immune response; B cell activation; B cell receptor signaling pathway; calcium-mediated signaling; immune response-regulating signaling pathway; immune system process; intracellular signal transduction; mast cell degranulation
Reference #:  Q9JHL0 (UniProtKB)
Alt. Names/Synonyms: AW125574; Lab; Lat2; Linker for activation of B-cells; linker for activation of T cells family, member 2; Linker for activation of T-cells family member 2; Membrane-associated adapter molecule; non-T cell activation linker; Non-T-cell activation linker; Ntal; Wbscr15; Wbscr5; Williams-Beuren syndrome chromosomal region 15 protein homolog; Williams-Beuren syndrome chromosome region 15 homolog; Williams-Beuren syndrome chromosome region 5 homolog; WSCR5
Gene Symbols: Lat2
Molecular weight: 22,876 Da
Basal Isoelectric point: 4.73  Predict pI for various phosphorylation states
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LAB

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene