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LAB
Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2. Highly expressed in spleen, peripheral blood lymphocytes, and germinal centers of lymph nodes. Also expressed in placenta, lung, pancreas and small intestine. Present in B-cells, NK cells and monocytes. Absent from T-cells (at protein level). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold; Membrane protein, integral |
| Chromosomal Location of mouse Ortholog: 5|5 G2 |
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Cellular Component:
membrane; membrane raft; plasma membrane
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Molecular Function:
SH2 domain binding
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Biological Process:
adaptive immune response; B cell activation; B cell receptor signaling pathway; calcium-mediated signaling; immune response-regulating signaling pathway; immune system process; intracellular signal transduction; mast cell degranulation
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Reference #:
Q9JHL0
(UniProtKB)
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Alt. Names/Synonyms: AW125574; Lab; Lat2; Linker for activation of B-cells; linker for activation of T cells family, member 2; Linker for activation of T-cells family member 2; Membrane-associated adapter molecule; non-T cell activation linker; Non-T-cell activation linker; Ntal; Wbsc; Wbscr; Wbscr15; Wbscr5; Williams-Beuren syndrome chromosomal region 15 protein homolog; Williams-Beuren syndrome chromosome region 15 homolog; Williams-Beuren syndrome chromosome region 5 homolog; WSCR5
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Gene Symbols: Lat2
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Molecular weight:
22,876 Da
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Basal Isoelectric point:
4.73
Predict pI for various phosphorylation states
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