PDLIM5 an adaptor protein of the Enigma family. Contains three LIM domains and one PDZ domain. LIM domains are cysteine-rich double zinc fingers composed of 50 to 60 amino acids that are involved in protein-protein interactions. LIM domain-containing proteins are scaffolds for the formation of multiprotein complexes. The proteins are involved in cytoskeleton organization, cell lineage specification, organ development, and oncogenesis. Enigma family proteins possess a 100-amino acid PDZ domain in the N terminus and 1 to 3 LIM domains in the C terminus. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 3|3 H1
Cellular Component:  actin cytoskeleton; cell junction; cell-cell adherens junction; cytoplasm; cytosol; filamentous actin; membrane; neuron projection; plasma membrane; postsynaptic density; postsynaptic membrane; stress fiber; synapse; Z disc
Molecular Function:  actin binding; actinin binding; metal ion binding; muscle alpha-actinin binding; protein binding; protein kinase C binding; protein N-terminus binding
Biological Process:  actin cytoskeleton organization; cell growth involved in cardiac muscle cell development; heart development; muscle structure development; regulation of dendritic spine morphogenesis; regulation of synapse assembly
Reference #:  Q8CI51 (UniProtKB)
Alt. Names/Synonyms: 1110001A05Rik; AI987914; C87059; Enh; Enh1; Enh2; Enh3; Enigma homolog; Enigma-like PDZ and LIM domains protein; LIM; PDLI5; Pdlim5; PDZ and LIM domain 5; PDZ and LIM domain protein 5
Gene Symbols: Pdlim5
Molecular weight: 63,299 Da
Basal Isoelectric point: 8.61  Predict pI for various phosphorylation states
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PDLIM5

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene