|
BIRC6
Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification. In the C-terminal section; belongs to the ubiquitin-conjugating enzyme family. Expressed in brain cancer cells. Note: This description may include information from UniProtKB.
|
| Protein type: EC 6.3.2.-; EC 6.3.2.19; Ubiquitin conjugating system; Ubiquitin ligase |
| Chromosomal Location of mouse Ortholog: 17|17 E2 |
|
Cellular Component:
cytoplasm; cytoskeleton; endosome; Golgi apparatus; membrane; microtubule organizing center; midbody; nucleus; spindle pole; trans-Golgi network
|
|
Molecular Function:
cysteine-type endopeptidase inhibitor activity; peptidase inhibitor activity; protein binding; transferase activity; ubiquitin conjugating enzyme activity; ubiquitin-protein transferase activity
|
|
Biological Process:
apoptotic process; cell cycle; cell division; cell population proliferation; labyrinthine layer development; negative regulation of apoptotic process; negative regulation of extrinsic apoptotic signaling pathway; negative regulation of peptidase activity; placenta development; positive regulation of cell population proliferation; protein ubiquitination; regulation of cell population proliferation; regulation of cytokinesis; spongiotrophoblast layer development
|
|
Reference #:
O88738
(UniProtKB)
|
|
Alt. Names/Synonyms: A430032G04Rik; A430040A19Rik; AA501170; accccbaculoviral IAP repeat-containing 6; apollon; baculoviral IAP repeat-containing 6; Baculoviral IAP repeat-containing protein 6; baculovirus inhibitor of apoptosis repeat containing ubiquitin-conjugating enzyme; BIR repeat-containing ubiquitin-conjugating enzyme; Birc6; Bruc; Bruce; D630005A10Rik; Kiaa1289; mKIAA1289; RING-type E3 ubiquitin transferase BIRC6; Ubiquitin-conjugating BIR domain enzyme apollon; Ubiquitin-conjugating enzyme
|
|
Gene Symbols: Birc6
|
|
Molecular weight:
532,170 Da
|
|
Basal Isoelectric point:
5.7
Predict pI for various phosphorylation states
|
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
|
