EPB41L3 Tumor suppressor that inhibits cell proliferation and promotes apoptosis. Modulates the activity of protein arginine N-methyltransferases, including PRMT3 and PRMT5. Expressed at high levels in brain, with lower levels in kidney, intestine, and testis. Detected in lung. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis; Tumor suppressor
Chromosomal Location of Human Ortholog: 17 E1.3|17 40.15 cM
Cellular Component:  cell junction; cell-cell junction; cytoplasm; cytoskeleton; juxtaparanode region of axon; membrane; paranode region of axon; plasma membrane; postsynaptic density
Molecular Function:  actin binding; cytoskeletal protein binding; structural constituent of cytoskeleton; structural molecule activity
Biological Process:  actomyosin structure organization; apoptotic process; cortical actin cytoskeleton organization; cortical cytoskeleton organization; cytoskeletal anchoring at plasma membrane; cytoskeleton organization; myelin maintenance; neuron projection morphogenesis; paranodal junction assembly; protein localization to juxtaparanode region of axon; protein localization to paranode region of axon; protein localization to plasma membrane; regulation of cell growth; regulation of cell shape
Reference #:  Q9WV92 (UniProtKB)
Alt. Names/Synonyms: 4.1B; Band 4.1-like protein 3; Band 4.1-like protein 3, N-terminally processed; DAL-1; Dal1; DAL1P; Differentially expressed in adenocarcinoma of the lung protein 1; E41L3; Epb4.1; Epb4.1l3; Epb41l3; erythrocyte membrane protein band 4.1 like 3; erythrocyte protein band 4.1-like 3; Kiaa0987; mDAL-1; NBL3
Gene Symbols: Epb41l3
Molecular weight: 103,338 Da
Basal Isoelectric point: 5.2  Predict pI for various phosphorylation states
Select Structure to View Below

EPB41L3

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene