| talin 1 Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts. Note: This description may include information from UniProtKB. |
| Protein type: Cytoskeletal; Motility/polarity/chemotaxis |
| Chromosomal Location of mouse Ortholog: 4|4 A5 |
| Cellular Component: adherens junction; anchoring junction; cell projection; cytoplasm; cytoskeleton; focal adhesion; membrane; plasma membrane; ruffle |
| Molecular Function: actin binding; actin filament binding; integrin binding; LIM domain binding; phosphatidylinositol binding; phosphatidylserine binding; protein binding; structural constituent of cytoskeleton; vinculin binding |
| Biological Process: cell adhesion; cell-cell adhesion; cell-substrate junction assembly; cortical actin cytoskeleton organization; integrin activation; integrin-mediated signaling pathway |
| Reference #: P26039 (UniProtKB) |
| Alt. Names/Synonyms: OTTMUSP00000007396; talin 1; Talin-1; talin1; Tln; Tln1 |
| Gene Symbols: Tln1 |
| Molecular weight: 269,821 Da |
| Basal Isoelectric point: 5.84 Predict pI for various phosphorylation states |
| CST Pathways: Growth And Differentiation Control by MAPKs | T Cell Receptor Signaling |
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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talin 1 |
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| Cross-references to other databases:
AlphaFold
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STRING
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Reactome
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BioGPS
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Pfam
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