GIT1 GTPase-activating protein for the ADP ribosylation factor family. May serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking, adhesion and cytoskeletal organization. Increases the speed of cell migration, as well as the size and rate of formation of protrusions, possibly by targeting PAK1 to adhesions and the leading edge of lamellipodia. Sequesters inactive non-tyrosine-phosphorylated paxillin in cytoplasmic complexes. Involved in the regulation of cytokinesis; the function may involve ENTR1 and PTPN13. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, ARF; Motility/polarity/chemotaxis
Chromosomal Location of mouse Ortholog: 11|11 B5
Cellular Component:  calyx of Held; cell junction; cell projection; centrosome; cytoplasm; cytoskeleton; cytosol; endosome; focal adhesion; GABA-ergic synapse; glutamatergic synapse; mitochondrion; mitotic spindle pole; neuron projection; postsynapse; synapse
Molecular Function:  gamma-tubulin binding; GTPase activator activity; identical protein binding; metal ion binding; protein binding; protein-containing complex binding; small GTPase binding; structural constituent of postsynaptic specialization
Biological Process:  brain development; cell redox homeostasis; cellular response to epidermal growth factor stimulus; cellular response to lipopolysaccharide; dendritic spine development; ephrin receptor signaling pathway; immunological synapse formation; intramembranous ossification; locomotory behavior; motor learning; negative regulation of ARF protein signal transduction; negative regulation of glycolytic process; negative regulation of inflammatory response to wounding; negative regulation of interleukin-1 beta production; neuron development; neurotransmitter receptor localization to postsynaptic specialization membrane; positive regulation of microtubule nucleation; positive regulation of receptor catabolic process; presynaptic modulation of chemical synaptic transmission; regulation of ARF protein signal transduction; regulation of cytokinesis; regulation of G protein-coupled receptor signaling pathway; regulation of synaptic vesicle exocytosis; synaptic vesicle recycling
Reference #:  Q68FF6 (UniProtKB)
Alt. Names/Synonyms: ARF GAP GIT1; ARF GTPase-activating protein GIT1; Cat-; Cat-1; G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein; G protein-coupled receptor kinase-interactor 1; GIT ArfGAP 1; Git1; GRK-interacting protein 1; OTTMUSP00000008532; p95C; p95Cat; RP23-81E16.3
Gene Symbols: Git1
Molecular weight: 85,300 Da
Basal Isoelectric point: 6.47  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein