GIT1 a multidomain, adaptor protein that regulates cellular processes by bringing together various signaling molecules, including PIX, PAK, paxillin, PTPN13. and PTPRZ1. May serve as a scaffold for signaling modules controlling vesicle trafficking, focal adhesion and cytoskeletal organization. GTPase-activating protein (GAP) for the ADP ribosylation factor (ARF) family. Its dynamic tyrosine phosphorylation appears to help coordinate cell motility. Regulates PLC-gamma activation by c-Src and integrates signal transduction by G protein coupled receptors (GPCR)s and tyrosine phosphorylation. Increases the speed of cell migration, as well as the size and rate of formation of protrusions, possibly by targeting PAK1 to adhesions and the leading edge of lamellipodia. Sequesters inactive non-tyrosine-phosphorylated paxillin in cytoplasmic complexes. Three human isoforms are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, ARF; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 11|11 B5
Cellular Component:  calyx of Held; cytoplasm; cytosol; endosome; focal adhesion; GABA-ergic synapse; glutamatergic synapse; neuron projection; postsynapse; synapse
Molecular Function:  GTPase activator activity; metal ion binding; protein binding; protein homodimerization activity; protein-containing complex binding; small GTPase binding; structural constituent of postsynaptic specialization
Biological Process:  cellular response to epidermal growth factor stimulus; dendritic spine development; ephrin receptor signaling pathway; immunological synapse formation; negative regulation of ARF protein signal transduction; neurotransmitter receptor localization to postsynaptic specialization membrane; positive regulation of receptor catabolic process; presynaptic modulation of chemical synaptic transmission; regulation of cytokinesis; regulation of G protein-coupled receptor signaling pathway; regulation of synaptic vesicle exocytosis
Reference #:  Q68FF6 (UniProtKB)
Alt. Names/Synonyms: ARF GAP GIT1; ARF GTPase-activating protein GIT1; Cat-1; G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein; G protein-coupled receptor kinase-interactor 1; Git1; GRK-interacting protein 1; OTTMUSP00000008532; p95Cat; RP23-81E16.3
Gene Symbols: Git1
Molecular weight: 85,300 Da
Basal Isoelectric point: 6.47  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein