CENTB2 a member of the centaurin family of ADP-ribosylation factor directed GTPase-activating proteins. Regulates cytoskeletal and membrane trafficking events in the cell periphery. Binding of phosphoinositides to a pleckstrin homology domain may regulate subcellular localization and activity. Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, ARF; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 16|16 B2
Cellular Component:  endosome; endosome membrane; membrane; ruffle
Molecular Function:  GTPase activator activity; metal ion binding; phosphatidylinositol-3,5-bisphosphate binding; protein binding; Rab GTPase binding
Biological Process:  actin filament-based process; cellular response to nerve growth factor stimulus; endocytic recycling
Reference #:  Q6ZQK5 (UniProtKB)
Alt. Names/Synonyms: 4832442G16; 9530039J15Rik; Acap2; Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2; ArfGAP with coiled-coil, ankyrin repeat and PH domains 2; centaurin, beta 2; centaurin-beta-2; Centb2; CNT-B2; mKIAA0041
Gene Symbols: Acap2
Molecular weight: 87,211 Da
Basal Isoelectric point: 6.25  Predict pI for various phosphorylation states
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CENTB2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein