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TR-beta1
Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine. Belongs to the nuclear hormone receptor family. NR1 subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding; Nuclear receptor |
| Chromosomal Location of mouse Ortholog: 14|14 A2 |
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Cellular Component:
nuclear body; nucleus; RNA polymerase II transcription regulator complex
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Molecular Function:
chromatin binding; chromatin DNA binding; DNA binding; DNA-binding transcription factor activity; double-stranded DNA binding; enzyme binding; identical protein binding; metal ion binding; nuclear receptor activity; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding; thyroid hormone binding; transcription coactivator binding; zinc ion binding
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Biological Process:
animal organ morphogenesis; cell differentiation; cellular response to thyroid hormone stimulus; female courtship behavior; mRNA transcription by RNA polymerase II; negative regulation of DNA-templated transcription; negative regulation of female receptivity; negative regulation of transcription by RNA polymerase II; positive regulation of cell population proliferation; positive regulation of chondrocyte differentiation; positive regulation of ossification; positive regulation of thyroid hormone mediated signaling pathway; positive regulation of transcription by RNA polymerase II; regulation of cholesterol metabolic process; regulation of DNA-templated transcription; regulation of heart contraction; regulation of lipid metabolic process; regulation of transcription by RNA polymerase II; regulation of triglyceride metabolic process; retinal cone cell apoptotic process; retinal cone cell development; retinoic acid receptor signaling pathway; sensory perception of sound; thyroid hormone mediated signaling pathway; type I pneumocyte differentiation
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Reference #:
P37242
(UniProtKB)
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Alt. Names/Synonyms: c-erbA-2; c-erbA-beta; c-erbAb; c-erbAbeta; Erba2; MGC141269; MGC141270; Nr1a2; Nuclear receptor subfamily 1 group A member 2; OTTMUSP00000027025; T3R[b; T3R[b]; T3Rbe; T3Rbeta; THB; Thrb; Thrb1; Thrb2; Thyroid hormone receptor beta; TR beta; TR-beta1
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Gene Symbols: Thrb
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Molecular weight:
52,630 Da
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Basal Isoelectric point:
6.95
Predict pI for various phosphorylation states
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