TR-beta1 Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine. Belongs to the nuclear hormone receptor family. NR1 subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Nuclear receptor
Chromosomal Location of Human Ortholog: 14|14 A2
Cellular Component:  nuclear body; nucleus; RNA polymerase II transcription factor complex
Molecular Function:  chromatin DNA binding; DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; double-stranded DNA binding; enzyme binding; metal ion binding; nuclear receptor activity; nuclear receptor transcription coactivator activity; protein binding; protein homodimerization activity; RNA polymerase II regulatory region sequence-specific DNA binding; sequence-specific DNA binding; signaling receptor activity; steroid hormone receptor activity; thyroid hormone binding; transcription factor binding; transcription regulatory region sequence-specific DNA binding; zinc ion binding
Biological Process:  animal organ morphogenesis; cell differentiation; female courtship behavior; hormone-mediated signaling pathway; multicellular organism development; negative regulation of eye photoreceptor cell development; negative regulation of female receptivity; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; positive regulation of cell proliferation; positive regulation of chondrocyte differentiation; positive regulation of ossification; positive regulation of transcription by RNA polymerase II; regulation of cholesterol metabolic process; regulation of heart contraction; regulation of lipid metabolic process; regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated; regulation of triglyceride metabolic process; response to lipid; retinal cone cell apoptotic process; retinal cone cell development; sensory perception of sound; thyroid gland development; thyroid hormone mediated signaling pathway; type I pneumocyte differentiation
Reference #:  P37242 (UniProtKB)
Alt. Names/Synonyms: c-erbA-2; c-erbA-beta; c-erbAbeta; Erba2; MGC141269; MGC141270; Nr1a2; Nuclear receptor subfamily 1 group A member 2; OTTMUSP00000027025; T3R[b]; T3Rbeta; THB; Thrb; Thrb1; Thrb2; Thyroid hormone receptor beta; TR beta
Gene Symbols: Thrb
Molecular weight: 52,630 Da
Basal Isoelectric point: 6.95  Predict pI for various phosphorylation states
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TR-beta1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA