TR-beta1 Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine. Belongs to the nuclear hormone receptor family. NR1 subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Nuclear receptor
Chromosomal Location of human Ortholog: 3p24.2
Cellular Component:  chromatin; nuclear body; nucleoplasm; nucleus; RNA polymerase II transcription regulator complex
Molecular Function:  chromatin DNA binding; DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; enzyme binding; nuclear receptor activity; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific double-stranded DNA binding; thyroid hormone binding; transcription coactivator binding; zinc ion binding
Biological Process:  cell differentiation; cellular response to thyroid hormone stimulus; DNA-templated transcription; female courtship behavior; mRNA transcription by RNA polymerase II; negative regulation of female receptivity; negative regulation of transcription by RNA polymerase II; positive regulation of thyroid hormone mediated signaling pathway; positive regulation of transcription by RNA polymerase II; regulation of heart contraction; retinal cone cell apoptotic process; retinal cone cell development; retinoic acid receptor signaling pathway; sensory perception of sound; thyroid hormone mediated signaling pathway; type I pneumocyte differentiation
Disease: Thyroid Hormone Resistance, Generalized, Autosomal Dominant; Thyroid Hormone Resistance, Generalized, Autosomal Recessive; Thyroid Hormone Resistance, Selective Pituitary
Reference #:  P10828 (UniProtKB)
Alt. Names/Synonyms: avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 2; c-erbA-2; c-erbA-beta; ERBA-BETA; ERBA2; GRTH; MGC126109; MGC126110; NR1A2; Nuclear receptor subfamily 1 group A member 2; oncogene ERBA2; PRTH; THB; THR1; THRB; THRB1; THRB2; thyroid hormone nuclear receptor beta variant 1; Thyroid hormone receptor beta; thyroid hormone receptor beta 1; thyroid hormone receptor beta isoform; thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian); TR-beta1
Gene Symbols: THRB
Molecular weight: 52,788 Da
Basal Isoelectric point: 6.68  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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