DAG1 The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization. Alpha-dystroglycan is an extracellular peripheral glycoprotein that acts as a receptor for both extracellular matrix proteins containing laminin-G domains. Receptor for laminin-2 (LAMA2) and agrin in peripheral nerve Schwann cells. Beta-dystroglycan is a transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity. (Microbial infection) Alpha-dystroglycan acts as a receptor for lassa virus and lymphocytic choriomeningitis virus glycoprotein and class C new-world arenaviruses. Alpha-dystroglycan acts as a Schwann cell receptor for Mycobacterium leprae, the causative organism of leprosy, but only in the presence of the G-domain of LAMA2. Expressed in a variety of fetal and adult tissues. In epidermal tissue, located to the basement membrane. Also expressed in keratinocytes and fibroblasts. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Membrane protein, integral; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 3p21.31
Cellular Component:  basement membrane; basolateral plasma membrane; cell-cell adherens junction; contractile ring; costamere; cytoplasm; cytoskeleton; cytosol; dystroglycan complex; dystrophin-associated glycoprotein complex; endoplasmic reticulum lumen; external side of plasma membrane; extracellular region; extracellular space; filopodium; GABA-ergic synapse; glutamatergic synapse; Golgi lumen; integral component of membrane; lamellipodium; node of Ranvier; nuclear periphery; nucleoplasm; plasma membrane; plasma membrane raft; postsynaptic cytosol; postsynaptic membrane; sarcolemma
Molecular Function:  actin binding; alpha-actinin binding; calcium ion binding; dystroglycan binding; laminin-1 binding; protein binding; SH2 domain binding; structural constituent of muscle; tubulin binding; vinculin binding; virus receptor activity
Biological Process:  aging; angiogenesis involved in wound healing; axon regeneration; basement membrane organization; branching involved in salivary gland morphogenesis; calcium-dependent cell-matrix adhesion; cellular response to cholesterol; cellular response to mechanical stimulus; commissural neuron axon guidance; cytoskeletal anchoring at plasma membrane; epithelial tube branching involved in lung morphogenesis; extracellular matrix organization; membrane protein ectodomain proteolysis; microtubule anchoring; modulation by virus of host morphology or physiology; morphogenesis of an epithelial sheet; myelination in peripheral nervous system; negative regulation of cell migration; negative regulation of MAPK cascade; negative regulation of protein kinase B signaling; nerve maturation; positive regulation of basement membrane assembly involved in embryonic body morphogenesis; positive regulation of cell-matrix adhesion; positive regulation of myelination; positive regulation of oligodendrocyte differentiation; positive regulation of protein kinase activity; regulation of embryonic cell shape; regulation of epithelial to mesenchymal transition; regulation of gastrulation; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane; regulation of synapse organization; response to denervation involved in regulation of muscle adaptation; response to peptide hormone; retrograde trans-synaptic signaling by trans-synaptic protein complex; skeletal muscle tissue regeneration; viral entry into host cell
Disease: Muscular Dystrophy-dystroglycanopathy (congenital With Brain And Eye Anomalies), Type A, 9; Muscular Dystrophy-dystroglycanopathy (limb-girdle), Type C, 9
Reference #:  Q14118 (UniProtKB)
Alt. Names/Synonyms: 156DAG; A3a; AGRNR; Alpha-DG; Alpha-dystroglycan; Beta-DG; Beta-dystroglycan; DAG; DAG1; Dystroglycan; dystroglycan 1; dystroglycan 1 (dystrophin-associated glycoprotein 1); Dystrophin-associated glycoprotein 1; LGMDR16; MDDGA9; MDDGC7; MDDGC9
Gene Symbols: DAG1
Molecular weight: 97,441 Da
Basal Isoelectric point: 8.71  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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