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FAK iso5
FRNK (FAK-related, non-kinase) is the C-terminal non-catalytic domain of FAK (pp125FAK) that is expressed as a separate protein in some cells.
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| Protein type: EC 2.7.10.2; Fak family; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); TK group |
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Cellular Component:
cell cortex; ciliary basal body; cytoplasm; dendritic spine; focal adhesion; nucleus; perinuclear region of cytoplasm; sarcolemma
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Molecular Function:
ATP binding; calcium-dependent cysteine-type endopeptidase activity; identical protein binding; molecular function activator activity; non-membrane spanning protein tyrosine kinase activity; protease binding; protein binding; protein tyrosine kinase activity
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Biological Process:
actin filament organization; angiogenesis; angiogenesis involved in wound healing; epidermal growth factor receptor signaling pathway; negative regulation of anoikis; negative regulation of cell-substrate adhesion; negative regulation of protein autophosphorylation; positive regulation of cell migration; positive regulation of cell population proliferation; positive regulation of focal adhesion assembly; positive regulation of protein binding; positive regulation of protein tyrosine kinase activity; positive regulation of substrate-dependent cell migration, cell attachment to substrate; protein autophosphorylation; protein phosphorylation; radial glia-guided pyramidal neuron migration; regulation of cell adhesion; response to muscle stretch; response to pH; signal complex assembly; wound healing, spreading of cells
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Reference #:
Q92063
(UniProtKB)
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Alt. Names/Synonyms: FAK iso5; Protein-tyrosine kinase
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Gene Symbols: PTK2
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Molecular weight:
39,793 Da
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Basal Isoelectric point:
5.85
Predict pI for various phosphorylation states
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CST Pathways:
Actin Dynamics
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Angiogenesis
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ErbB/HER Signaling
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GPCR Signaling to MAPKs
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Growth And Differentiation Control by MAPKs
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PI3K/Akt Signaling
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Tyrosine Kinases & Substrates
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