PRLR receptor for the anterior pituitary hormone prolactin and placental lactogen I and II. Interacts with Cyclophilin A, differentially regulating various signaling pathways from the PrlR. Prolactin signaling is attenuated by threonine and tyrosine phosphorylation. Two alternative splice isoforms have been identified. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, cytokine
Chromosomal Location of Human Ortholog: 2q16
Cellular Component:  cell surface; external side of plasma membrane; integral component of membrane; intracellular; plasma membrane; receptor complex
Molecular Function:  cytokine binding; hematopoietin/interferon-class (D200-domain) cytokine receptor activity; metal ion binding; peptide hormone binding; prolactin receptor activity; protein kinase binding
Biological Process:  activation of transmembrane receptor protein tyrosine kinase activity; JAK-STAT cascade; lactation; prolactin signaling pathway; regulation of cell adhesion; regulation of epithelial cell differentiation
Reference #:  P05710 (UniProtKB)
Alt. Names/Synonyms: Lactogen receptor; MGC105486; PRL-R; Prlr; Prolactin receptor; RATPRLR
Gene Symbols: Prlr
Molecular weight: 68,599 Da
Basal Isoelectric point: 5.11  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene