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PRLR
This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling. Belongs to the type I cytokine receptor family. Type 1 subfamily. Expressed in breast, placenta, kidney, liver and pancreas. 9 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral; Receptor, cytokine |
| Chromosomal Location of rat Ortholog: 2q16 |
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Cellular Component:
cell surface; external side of plasma membrane; membrane; plasma membrane; receptor complex
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Molecular Function:
cytokine binding; cytokine receptor activity; lipid binding; metal ion binding; peptide hormone binding; prolactin receptor activity; protein kinase binding
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Biological Process:
activation of Janus kinase activity; activation of transmembrane receptor protein tyrosine kinase activity; cellular response to granulocyte macrophage colony-stimulating factor stimulus; cytokine-mediated signaling pathway; lactation; mammary gland alveolus development; mammary gland epithelial cell differentiation; mammary gland epithelium development; negative regulation of apoptotic process; positive regulation of B cell proliferation; positive regulation of cell population proliferation; positive regulation of cold-induced thermogenesis; positive regulation of protein autophosphorylation; prolactin signaling pathway; prostate gland growth; receptor signaling pathway via JAK-STAT; regulation of cell adhesion; regulation of epithelial cell differentiation; response to bacterium
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Reference #:
P05710
(UniProtKB)
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Alt. Names/Synonyms: Lactogen receptor; MGC105486; PRL-R; Prlr; Prolactin receptor; RATPRLR
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Gene Symbols: Prlr
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Molecular weight:
68,599 Da
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Basal Isoelectric point:
5.11
Predict pI for various phosphorylation states
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