PRLR This is a receptor for the anterior pituitary hormone prolactin (PRL). Acts as a prosurvival factor for spermatozoa by inhibiting sperm capacitation through suppression of SRC kinase activation and stimulation of AKT. Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling. Belongs to the type I cytokine receptor family. Type 1 subfamily. Expressed in breast, placenta, kidney, liver and pancreas. 9 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, cytokine
Chromosomal Location of human Ortholog: 5p13.2
Cellular Component:  cell surface; endosome lumen; external side of plasma membrane; extracellular region; plasma membrane; receptor complex
Molecular Function:  cytokine binding; lipid binding; metal ion binding; peptide hormone binding; prolactin receptor activity; protein binding; protein kinase binding
Biological Process:  activation of Janus kinase activity; activation of transmembrane receptor protein tyrosine kinase activity; cellular response to granulocyte macrophage colony-stimulating factor stimulus; cytokine-mediated signaling pathway; embryo implantation; lactation; mammary gland alveolus development; mammary gland epithelial cell differentiation; negative regulation of apoptotic process; positive regulation of B cell proliferation; positive regulation of cell population proliferation; positive regulation of cold-induced thermogenesis; positive regulation of protein autophosphorylation; prolactin signaling pathway; prostate gland growth; receptor signaling pathway via JAK-STAT; regulation of cell adhesion; regulation of epithelial cell differentiation; response to bacterium; steroid biosynthetic process
Disease: Hyperprolactinemia; Multiple Fibroadenomas Of The Breast
Reference #:  P16471 (UniProtKB)
Alt. Names/Synonyms: delta 4-delta 7/11 truncated prolactin receptor; delta 4-SF1b truncated prolactin receptor; HPRL; hPRL receptor; hPRLrI; MFAB; PRL-R; PRLR; Prolactin receptor; prolactin receptor delta 7/11; RI-PRLR; secreted prolactin binding protein
Gene Symbols: PRLR
Molecular weight: 69,506 Da
Basal Isoelectric point: 5.23  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein