CPEB Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR. RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism. In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation. Involved in the transport of CPE-containing mRNA to dendrites; those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses. Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation. Induces the assembly of stress granules in the absence of stress. Required for cell cycle progression, specifically for prophase entry. Belongs to the RRM CPEB family. Isoform 1 is expressed in immature oocytes, ovary, brain and heart. Isoform 2 is expressed in brain and heart. Isoform 3 and isoform 4 are expressed in brain. Expressed in breast tumors and several tumor cell lines. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA-binding; Translation
Chromosomal Location of Human Ortholog: 15q25.2
Cellular Component:  cell junction; cytoplasm; cytosol; dendrite; nucleoplasm; nucleus; P-body; postsynaptic density; postsynaptic membrane
Molecular Function:  metal ion binding; mRNA 3'-UTR AU-rich region binding; protein binding; translation repressor activity, mRNA regulatory element binding
Biological Process:  cellular response to amino acid stimulus; cellular response to hypoxia; cellular response to insulin stimulus; mRNA processing; negative regulation of cytoplasmic translation; positive regulation of mRNA polyadenylation; translation
Reference #:  Q9BZB8 (UniProtKB)
Alt. Names/Synonyms: CEBP; CPE-binding protein 1; CPE-BP1; CPEB; CPEB-1; CPEB1; cytoplasmic polyadenylation element binding protein 1; Cytoplasmic polyadenylation element-binding protein 1; FLJ13203; h-CEBP; h-CPEB; hCPEB-1; MGC34136; MGC60106
Gene Symbols: CPEB1
Molecular weight: 62,595 Da
Basal Isoelectric point: 7.55  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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CPEB

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene