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CPEB
Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR. RNA binding results in a clear conformational change analogous to the Venus fly trap mechanism. In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation. Involved in the transport of CPE-containing mRNA to dendrites; those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses. Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation. Induces the assembly of stress granules in the absence of stress. Required for cell cycle progression, specifically for prophase entry. Belongs to the RRM CPEB family. Isoform 1 is expressed in immature oocytes, ovary, brain and heart. Isoform 2 is expressed in brain and heart. Isoform 3 and isoform 4 are expressed in brain. Expressed in breast tumors and several tumor cell lines. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: RNA-binding; Translation |
| Chromosomal Location of mouse Ortholog: 7|7 D3 |
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Cellular Component:
centrosome; cytoplasm; cytosol; glutamatergic synapse; growth cone; meiotic spindle; membrane; messenger ribonucleoprotein complex; neuron projection; neuronal cell body; nucleoplasm; nucleus; perinuclear region of cytoplasm; postsynapse; postsynaptic density; ribonucleoprotein complex; synapse
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Molecular Function:
metal ion binding; mRNA 3'-UTR AU-rich region binding; mRNA 3'-UTR binding; mRNA binding; mRNA regulatory element binding translation repressor activity; nucleic acid binding; protein binding; ribosome binding; RNA binding; translation factor activity, RNA binding; translation regulator activity
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Biological Process:
cellular response to amino acid stimulus; cellular response to hypoxia; cellular response to insulin stimulus; mRNA processing; mRNA transport; negative regulation of cell population proliferation; negative regulation of cytoplasmic translation; negative regulation of translation; positive regulation of cell migration; positive regulation of neuron projection development; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of translation; regulation of neuronal synaptic plasticity; regulation of translation; regulation of translation at synapse, modulating synaptic transmission; synaptonemal complex assembly
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Reference #:
P70166
(UniProtKB)
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Alt. Names/Synonyms: AU024112; CPE-binding protein 1; CPE-BP1; Cpeb; Cpeb1; cytoplasmic polyadenylation element binding protein 1; Cytoplasmic polyadenylation element-binding protein 1; mCPEB; mCPEB-1; MGC159179; OTTMUSP00000029472
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Gene Symbols: Cpeb1
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Molecular weight:
61,917 Da
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Basal Isoelectric point:
7.86
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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