KOR-1 G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions. Belongs to the G-protein coupled receptor 1 family. Detected in brain and placenta. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of rat Ortholog: 5q12
Cellular Component:  axon terminus; cytosol; dendrite; integral component of membrane; integral component of plasma membrane; integral component of postsynaptic membrane; integral component of presynaptic membrane; integral component of synaptic vesicle membrane; neuronal cell body; nucleus; perikaryon; plasma membrane; synapse
Molecular Function:  dynorphin receptor activity; G protein-coupled receptor activity; neuropeptide binding; opioid receptor activity; peptide binding; protein binding; receptor serine/threonine kinase binding
Biological Process:  adenylate cyclase-inhibiting opioid receptor signaling pathway; behavioral response to cocaine; cellular response to glucose stimulus; cellular response to lipopolysaccharide; conditioned place preference; defense response to virus; eating behavior; estrous cycle; immune response; locomotory behavior; maternal behavior; negative regulation of luteinizing hormone secretion; neuropeptide signaling pathway; opioid receptor signaling pathway; phospholipase C-activating G protein-coupled receptor signaling pathway; positive regulation of dopamine secretion; positive regulation of eating behavior; positive regulation of locomotion; positive regulation of neuronal action potential; positive regulation of p38MAPK cascade; positive regulation of potassium ion transmembrane transport; regulation of saliva secretion; regulation of sensory perception of pain; response to acrylamide; response to auditory stimulus; response to cocaine; response to estrogen; response to ethanol; response to insulin; response to morphine; response to radiation; sensory perception of pain; sensory perception of temperature stimulus
Reference #:  P34975 (UniProtKB)
Alt. Names/Synonyms: K-OR-1; Kappa-type opioid receptor; KOR-1; opioid receptor, kappa 1; OPRK; Oprk1; Ror-d
Gene Symbols: Oprk1
Molecular weight: 42,688 Da
Basal Isoelectric point: 8.2  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene