IL10RA Cell surface receptor for the cytokine IL10 that participates in IL10-mediated anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Upon binding to IL10, induces a conformational change in IL10RB, allowing IL10RB to bind IL10 as well. In turn, the heterotetrameric assembly complex, composed of two subunits of IL10RA and IL10RB, activates the kinases JAK1 and TYK2 that are constitutively associated with IL10RA and IL10RB respectively. These kinases then phosphorylate specific tyrosine residues in the intracellular domain in IL10RA leading to the recruitment and subsequent phosphorylation of STAT3. Once phosphorylated, STAT3 homodimerizes, translocates to the nucleus and activates the expression of anti-inflammatory genes. In addition, IL10RA-mediated activation of STAT3 inhibits starvation-induced autophagy. Belongs to the type II cytokine receptor family. Primarily expressed in hematopoetic cells including B-cells, T-cells, NK cells, monocytes and macrophages. Not expresssed in non-hematopoetic cells such as fibroblasts or endothelial cells. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, cytokine
Chromosomal Location of mouse Ortholog: 9 A5.2|9 24.84 cM
Cellular Component:  apical plasma membrane; cytoplasm; cytosol; membrane; plasma membrane
Molecular Function:  interleukin-10 binding; interleukin-10 receptor activity
Biological Process:  cytokine-mediated signaling pathway; intestinal epithelial structure maintenance; negative regulation of autophagy; negative regulation of inflammatory response; positive regulation of receptor signaling pathway via JAK-STAT; regulation of synapse organization; ubiquitin-dependent endocytosis
Reference #:  Q61727 (UniProtKB)
Alt. Names/Synonyms: AW553859; CD210; CDw210; CDw210a; I10R1; IL-10 receptor subunit alpha; IL-10R subunit 1; IL-10R subunit alpha; IL-10R-A; IL-10R1; IL-10RA; Il10r; Il10ra; interleukin 10 receptor, alpha; Interleukin-10 receptor subunit 1; Interleukin-10 receptor subunit alpha; mIL-; mIL-10R
Gene Symbols: Il10ra
Molecular weight: 64,248 Da
Basal Isoelectric point: 5.11  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein