IL10RA a receptor for interleukin 10 structurally related to interferon receptors. Mediates the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, cytokine
Chromosomal Location of Human Ortholog: 11q23.3
Cellular Component:  cytoplasm; integral component of membrane; plasma membrane
Molecular Function:  interleukin-10 binding; protein binding; signaling receptor activity
Biological Process:  cytokine-mediated signaling pathway; negative regulation of autophagy; positive regulation of JAK-STAT cascade; regulation of synapse organization; response to lipopolysaccharide; ubiquitin-dependent endocytosis
Disease: Inflammatory Bowel Disease 28, Autosomal Recessive
Reference #:  Q13651 (UniProtKB)
Alt. Names/Synonyms: CDW210A; HIL-10R; I10R1; IL-10 receptor subunit alpha; IL-10R subunit 1; IL-10R subunit alpha; IL-10R-A; IL-10R1; IL-10RA; IL10R; IL10RA; interleukin 10 receptor, alpha; interleukin-10 receptor alpha chain; Interleukin-10 receptor subunit 1; Interleukin-10 receptor subunit alpha
Gene Symbols: IL10RA
Molecular weight: 63,003 Da
Basal Isoelectric point: 5.23  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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