ROMK In the kidney, probably plays a major role in potassium homeostasis. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium. Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ1 subfamily. In the kidney and pancreatic islets. Lower levels in skeletal muscle, pancreas, spleen, brain, heart and liver. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of human Ortholog: 11q24.3
Cellular Component:  plasma membrane; voltage-gated potassium channel complex
Molecular Function:  ATP binding; phosphatidylinositol-4,5-bisphosphate binding
Biological Process:  excretion; potassium ion transport; regulation of ion transmembrane transport
Disease: Bartter Syndrome, Antenatal, Type 2
Reference #:  P48048 (UniProtKB)
Alt. Names/Synonyms: ATP-regulated potassium channel ROM-K; ATP-sensitive inward rectifier potassium channel 1; Inward rectifier K(+) channel Kir1.1; inwardly rectifying K+ channel; IRK1; KCNJ1; KIR1.1; Potassium channel, inwardly rectifying subfamily J member 1; potassium inwardly rectifying channel subfamily J member 1; potassium inwardly-rectifying channel J1; potassium inwardly-rectifying channel, subfamily J, member 1; potassium voltage-gated channel subfamily J member 1; ROMK; ROMK1
Gene Symbols: KCNJ1
Molecular weight: 44,795 Da
Basal Isoelectric point: 9.03  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein