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ROMK
In the kidney, probably plays a major role in potassium homeostasis. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium. Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ1 subfamily. In the kidney and pancreatic islets. Lower levels in skeletal muscle, pancreas, spleen, brain, heart and liver. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass |
| Chromosomal Location of rat Ortholog: 8q21 |
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Cellular Component:
membrane; plasma membrane
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Molecular Function:
ATP binding; ATP-activated inward rectifier potassium channel activity; inward rectifier potassium channel activity; peptide binding; phosphatidylinositol-4,5-bisphosphate binding; potassium ion binding
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Biological Process:
cellular response to magnesium ion; circulatory system development; gene expression; kidney development; negative regulation of apoptotic process; post-embryonic development; potassium ion import across plasma membrane; potassium ion transport; regulation of G-protein activated inward rectifier potassium channel activity; regulation of monoatomic ion transmembrane transport; renal sodium ion absorption; response to potassium ion; tissue homeostasis
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Disease: Bartter Syndrome, Antenatal, Type 1
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Reference #:
P35560
(UniProtKB)
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Alt. Names/Synonyms: ATP-regulated potassium channel ROM-K; ATP-sensitive inward rectifier potassium channel 1; Inward rectifier K(+) channel Kir1.1; IRK1; K+ channel protein; KAB-1; Kcnj; Kcnj1; kir1.1; Potassium channel, inwardly rectifying subfamily J member 1; Potassium inwardly-rectifying channel subfamily J; potassium inwardly-rectifying channel, subfamily J, member 1; ROMK; Romk1
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Gene Symbols: Kcnj1
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Molecular weight:
44,963 Da
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Basal Isoelectric point:
9.09
Predict pI for various phosphorylation states
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