ROMK an inward rectifier-type potassium channel protein. Probably plays a major role in potassium homeostasis in the kidney. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. The channel is activated by internal ATP and can be blocked by external barium. High levels of expression in the kidney and pancreatic islets. Lower levels in skeletal muscle, pancreas, spleen, brain, heart and liver. Three alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 8q21
Cellular Component:  integral component of membrane; plasma membrane
Molecular Function:  ATP binding; ATP-activated inward rectifier potassium channel activity; inward rectifier potassium channel activity; peptide binding; phosphatidylinositol-4,5-bisphosphate binding; potassium ion binding
Biological Process:  cardiovascular system development; cellular response to magnesium ion; kidney development; negative regulation of apoptotic process; post-embryonic development; potassium ion import across plasma membrane; potassium ion transmembrane transport; potassium ion transport; regulation of G-protein activated inward rectifier potassium channel activity; regulation of ion transmembrane transport; renal sodium ion absorption; response to potassium ion; tissue homeostasis
Disease: Bartter Syndrome, Antenatal, Type 1
Reference #:  P35560 (UniProtKB)
Alt. Names/Synonyms: ATP-regulated potassium channel ROM-K; ATP-sensitive inward rectifier potassium channel 1; Inward rectifier K(+) channel Kir1.1; IRK1; K+ channel protein; KAB-1; Kcnj; Kcnj1; kir1.1; Potassium channel, inwardly rectifying subfamily J member 1; Potassium inwardly-rectifying channel subfamily J; potassium inwardly-rectifying channel, subfamily J, member 1; Romk1
Gene Symbols: Kcnj1
Molecular weight: 44,963 Da
Basal Isoelectric point: 9.09  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene