GATA4 Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development and function. In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it downregulates endocardial and endothelial gene expression. Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions. Acts as a transcriptional activator of ANF in cooperation with NKX2-5. Promotes cardiac myocyte enlargement. Required during testicular development. May play a role in sphingolipid signaling by regulating the expression of sphingosine-1-phosphate degrading enzyme, spingosine-1-phosphate lyase. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Transcription factor
Chromosomal Location of human Ortholog: 8p23.1
Cellular Component:  nuclear body; nucleoplasm; nucleus; RNA polymerase II transcription factor complex
Molecular Function:  activating transcription factor binding; co-SMAD binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; enhancer sequence-specific DNA binding; NFAT protein binding; protein binding; protein kinase binding; RNA polymerase II regulatory region sequence-specific DNA binding; RNA polymerase II transcription factor binding; sequence-specific DNA binding; transcription coactivator activity; transcription factor binding; transcription regulatory region DNA binding; zinc ion binding
Biological Process:  aortic valve morphogenesis; atrial septum morphogenesis; atrial septum primum morphogenesis; atrial septum secundum morphogenesis; atrioventricular valve formation; blood coagulation; cardiac muscle tissue regeneration; cardiac right ventricle morphogenesis; cardiac ventricle morphogenesis; cell growth involved in cardiac muscle cell development; cell-cell signaling; cellular response to glucose stimulus; embryonic foregut morphogenesis; embryonic heart tube anterior/posterior pattern specification; endocardial cushion development; endoderm development; heart looping; intestinal epithelial cell differentiation; male gonad development; negative regulation of apoptotic signaling pathway; negative regulation of autophagy; negative regulation of cardiac muscle cell apoptotic process; negative regulation of oxidative stress-induced cell death; positive regulation of angiogenesis; positive regulation of BMP signaling pathway; positive regulation of cardioblast differentiation; positive regulation of ERK1 and ERK2 cascade; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; positive regulation of vascular endothelial growth factor production; regulation of cardiac muscle cell contraction; regulation of protein kinase B signaling; regulation of transcription, DNA-templated; response to drug; response to mechanical stimulus; response to vitamin A; transdifferentiation; ventricular septum development
Disease: Atrial Septal Defect 2; Atrioventricular Septal Defect 4; Testicular Anomalies With Or Without Congenital Heart Disease; Tetralogy Of Fallot; Ventricular Septal Defect 1
Reference #:  P43694 (UniProtKB)
Alt. Names/Synonyms: ASD2; GATA binding protein 4; GATA-binding factor 4; GATA-binding protein 4; GATA4; MGC126629; TACHD; TOF; Transcription factor GATA-4; VSD1
Gene Symbols: GATA4
Molecular weight: 44,565 Da
Basal Isoelectric point: 9.39  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB