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GATA4
Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development and function. In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it downregulates endocardial and endothelial gene expression. Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions. Acts as a transcriptional activator of ANF in cooperation with NKX2-5. Promotes cardiac myocyte enlargement. Required during testicular development. May play a role in sphingolipid signaling by regulating the expression of sphingosine-1-phosphate degrading enzyme, spingosine-1-phosphate lyase. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Motility/polarity/chemotaxis; Transcription factor |
| Chromosomal Location of human Ortholog: 8p23.1 |
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Cellular Component:
chromatin; nuclear body; nucleoplasm; nucleus; RNA polymerase II transcription regulator complex
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Molecular Function:
co-SMAD binding; DNA binding; DNA-binding transcription activator activity; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; NFAT protein binding; protein binding; protein kinase binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding; transcription cis-regulatory region binding; zinc ion binding
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Biological Process:
aortic valve morphogenesis; atrial septum morphogenesis; atrial septum primum morphogenesis; atrial septum secundum morphogenesis; atrioventricular canal development; atrioventricular node development; atrioventricular valve formation; cardiac muscle tissue regeneration; cardiac right ventricle morphogenesis; cardiac ventricle morphogenesis; cell fate commitment; cell growth involved in cardiac muscle cell development; cell-cell signaling; cellular response to glucose stimulus; embryonic foregut morphogenesis; embryonic heart tube anterior/posterior pattern specification; endocardial cushion development; endoderm development; heart looping; intestinal epithelial cell differentiation; male gonad development; negative regulation of apoptotic signaling pathway; negative regulation of autophagy; negative regulation of cardiac muscle cell apoptotic process; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; negative regulation of transcription by RNA polymerase II; positive regulation of angiogenesis; positive regulation of BMP signaling pathway; positive regulation of DNA-templated transcription; positive regulation of ERK1 and ERK2 cascade; positive regulation of transcription by RNA polymerase II; positive regulation of vascular endothelial growth factor production; regulation of cardiac muscle cell contraction; regulation of DNA-templated transcription; regulation of protein kinase B signaling; response to mechanical stimulus; response to vitamin A; response to xenobiotic stimulus; transdifferentiation; ventricular septum development; wound healing
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Disease: Atrial Septal Defect 2; Atrioventricular Septal Defect 4; Testicular Anomalies With Or Without Congenital Heart Disease; Tetralogy Of Fallot; Ventricular Septal Defect 1
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Reference #:
P43694
(UniProtKB)
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Alt. Names/Synonyms: ASD2; GATA binding protein 4; GATA-binding factor 4; GATA-binding protein 4; GATA4; MGC126629; TACHD; TOF; Transcription factor GATA-4; VSD1
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Gene Symbols: GATA4
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Molecular weight:
44,565 Da
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Basal Isoelectric point:
9.39
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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