GATA4 Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development and function. In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it downregulates endocardial and endothelial gene expression. Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions. Acts as a transcriptional activator of ANF in cooperation with NKX2-5. Promotes cardiac myocyte enlargement. Required during testicular development. May play a role in sphingolipid signaling by regulating the expression of sphingosine-1-phosphate degrading enzyme, spingosine-1-phosphate lyase. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Transcription factor
Chromosomal Location of Human Ortholog: 15p12
Cellular Component:  nuclear body; nuclear chromatin; nucleus; RNA polymerase II transcription factor complex
Molecular Function:  activating transcription factor binding; chromatin binding; co-SMAD binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; enhancer sequence-specific DNA binding; NFAT protein binding; protein kinase binding; RNA polymerase II proximal promoter sequence-specific DNA binding; RNA polymerase II regulatory region sequence-specific DNA binding; RNA polymerase II transcription factor binding; sequence-specific DNA binding; transcription coactivator activity; transcription factor binding; transcription regulatory region DNA binding; transcription regulatory region sequence-specific DNA binding; zinc ion binding
Biological Process:  aortic valve morphogenesis; atrial septum morphogenesis; atrial septum primum morphogenesis; atrial septum secundum morphogenesis; atrioventricular canal development; atrioventricular valve formation; atrioventricular valve morphogenesis; BMP signaling pathway; canonical Wnt signaling pathway; cardiac muscle cell differentiation; cardiac muscle hypertrophy in response to stress; cardiac muscle tissue development; cardiac muscle tissue regeneration; cardiac right ventricle morphogenesis; cardiac septum development; cell growth involved in cardiac muscle cell development; cell-cell signaling; cellular response to follicle-stimulating hormone stimulus; cellular response to glucose stimulus; cellular response to gonadotropin stimulus; embryonic digestive tract morphogenesis; embryonic foregut morphogenesis; embryonic heart tube anterior/posterior pattern specification; embryonic heart tube development; embryonic morphogenesis; endocardial cushion development; endoderm formation; epithelial cell fate commitment; gastrulation with mouth forming second; heart development; heart looping; heart morphogenesis; in utero embryonic development; intestinal epithelial cell differentiation; lung lobe formation; male gonad development; negative regulation of apoptotic process; negative regulation of apoptotic signaling pathway; negative regulation of autophagy; negative regulation of cardiac muscle cell apoptotic process; negative regulation of connective tissue replacement; negative regulation of gene expression; negative regulation of oxidative stress-induced cell death; positive regulation of angiogenesis; positive regulation of BMP signaling pathway; positive regulation of cardiac muscle cell proliferation; positive regulation of cardioblast differentiation; positive regulation of cell cycle; positive regulation of ERK1 and ERK2 cascade; positive regulation of gene expression; positive regulation of protein phosphorylation; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; positive regulation of vascular endothelial growth factor production; regulation of cardiac muscle cell contraction; regulation of cardiac muscle cell proliferation; regulation of gene expression; regulation of protein kinase B signaling; regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated; response to drug; response to estrogen; response to mechanical stimulus; response to retinoic acid; response to vitamin A; seminiferous tubule development; Sertoli cell differentiation; signal transduction involved in regulation of gene expression; SMAD protein signal transduction; spermatogenesis; transcription by RNA polymerase II; transdifferentiation; tube morphogenesis; ventricular cardiac muscle tissue development; ventricular septum development
Reference #:  P46152 (UniProtKB)
Alt. Names/Synonyms: DNA-binding protein GATA-GT2; GATA binding protein 4; GATA-binding factor 4; GATA-binding protein 4; Gata4; Transcription factor GATA-4
Gene Symbols: Gata4
Molecular weight: 44,597 Da
Basal Isoelectric point: 9.39  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene