GATA4
Transcriptional activator that binds to the consensus sequence 5'-AGATAG-3' and plays a key role in cardiac development and function. In cooperation with TBX5, it binds to cardiac super-enhancers and promotes cardiomyocyte gene expression, while it downregulates endocardial and endothelial gene expression. Involved in bone morphogenetic protein (BMP)-mediated induction of cardiac-specific gene expression. Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions. Acts as a transcriptional activator of ANF in cooperation with NKX2-5. Promotes cardiac myocyte enlargement. Required during testicular development. May play a role in sphingolipid signaling by regulating the expression of sphingosine-1-phosphate degrading enzyme, spingosine-1-phosphate lyase. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
Protein type: Motility/polarity/chemotaxis; Transcription factor |
Chromosomal Location of mouse Ortholog: 14 D1|14 33.24 cM |
Cellular Component:
chromatin; nuclear body; nucleoplasm; nucleus; RNA polymerase II transcription regulator complex
|
Molecular Function:
chromatin binding; cis-regulatory region sequence-specific DNA binding; co-SMAD binding; DNA binding; DNA-binding transcription activator activity; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor binding; metal ion binding; NFAT protein binding; protein binding; protein kinase binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding; transcription cis-regulatory region binding; transcription coactivator binding; zinc ion binding
|
Biological Process:
aortic valve morphogenesis; atrial septum morphogenesis; atrial septum primum morphogenesis; atrial septum secundum morphogenesis; atrioventricular canal development; atrioventricular valve formation; atrioventricular valve morphogenesis; cardiac muscle cell differentiation; cardiac muscle cell proliferation; cardiac muscle hypertrophy in response to stress; cardiac muscle tissue development; cardiac muscle tissue regeneration; cardiac right ventricle morphogenesis; cardiac septum development; cell fate commitment; cell growth involved in cardiac muscle cell development; cell-cell signaling; cellular response to follicle-stimulating hormone stimulus; cellular response to gonadotropin stimulus; diaphragm morphogenesis; embryonic digestive tract morphogenesis; embryonic foregut morphogenesis; embryonic heart tube anterior/posterior pattern specification; embryonic heart tube development; embryonic morphogenesis; endocardial cushion development; endoderm formation; epithelial cell fate commitment; gastrulation with mouth forming second; heart development; heart looping; heart morphogenesis; in utero embryonic development; intestinal epithelial cell differentiation; lung lobe formation; lung morphogenesis; male gonad development; mitral valve formation; negative regulation of apoptotic process; negative regulation of apoptotic signaling pathway; negative regulation of autophagy; negative regulation of cardiac muscle cell apoptotic process; negative regulation of connective tissue replacement; negative regulation of gene expression; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; negative regulation of transcription by RNA polymerase II; outflow tract morphogenesis; positive regulation of angiogenesis; positive regulation of BMP signaling pathway; positive regulation of cardiac muscle cell proliferation; positive regulation of cell cycle; positive regulation of DNA-templated transcription; positive regulation of ERK1 and ERK2 cascade; positive regulation of gene expression; positive regulation of protein phosphorylation; positive regulation of transcription by RNA polymerase II; positive regulation of vascular endothelial growth factor production; regulation of cardiac muscle cell contraction; regulation of cardiac muscle cell proliferation; regulation of DNA-templated transcription; regulation of gene expression; regulation of protein kinase B signaling; regulation of transcription by RNA polymerase II; response to estrogen; response to mechanical stimulus; response to retinoic acid; response to xenobiotic stimulus; seminiferous tubule development; Sertoli cell differentiation; signal transduction involved in regulation of gene expression; skeletal muscle cell differentiation; SMAD protein signal transduction; spermatogenesis; transdifferentiation; tricuspid valve formation; tube morphogenesis; vasculogenesis involved in coronary vascular morphogenesis; ventricular cardiac muscle tissue development; ventricular septum development; wound healing
|
Reference #:
Q08369
(UniProtKB)
|
Alt. Names/Synonyms: Gata; GATA binding protein 4; Gata-4; GATA-binding factor 4; GATA-binding protein 4; Gata4; Transcription factor GATA-4
|
Gene Symbols: Gata4
|
Molecular weight:
44,580 Da
|
Basal Isoelectric point:
9.39
Predict pI for various phosphorylation states
|
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
|