CDC25A a member of the MPI phosphatase family. Functions as a dosage-dependent inducer in mitotic control.. Required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC; Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity
Chromosomal Location of Human Ortholog: 8q32
Cellular Component:  cytoplasm; nucleus
Molecular Function:  chaperone binding; phosphoprotein phosphatase activity; protein kinase binding; protein tyrosine phosphatase activity
Biological Process:  cell division; cellular response to UV; G1/S transition of mitotic cell cycle; G2/M transition of mitotic cell cycle; peptidyl-tyrosine dephosphorylation; positive regulation of cell cycle G2/M phase transition; positive regulation of G2/M transition of mitotic cell cycle; positive regulation of G2/MI transition of meiotic cell cycle; positive regulation of mitotic cell cycle; response to radiation
Reference #:  P48965 (UniProtKB)
Alt. Names/Synonyms: Cdc25a; cell division cycle 25 homolog A (S. pombe); cell division cycle 25A; Dual specificity phosphatase Cdc25A; M-phase inducer phosphatase 1; MPIP1
Gene Symbols: Cdc25a
Molecular weight: 59,218 Da
Basal Isoelectric point: 6.67  Predict pI for various phosphorylation states
CST Pathways:  G1/S Checkpoint  |  G2/M DNA Damage Checkpoint
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene