|
CDC25A
Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly dephosphorylates CDK1 and stimulates its kinase activity. Also dephosphorylates CDK2 in complex with cyclin E, in vitro. Belongs to the MPI phosphatase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity |
| Chromosomal Location of rat Ortholog: 8q32 |
|
Cellular Component:
cytoplasm; nucleus
|
|
Molecular Function:
phosphoprotein phosphatase activity; protein kinase binding; protein tyrosine phosphatase activity; protein-folding chaperone binding
|
|
Biological Process:
cell division; cellular response to UV; G1/S transition of mitotic cell cycle; G2/M transition of mitotic cell cycle; positive regulation of cell cycle G2/M phase transition; positive regulation of cholangiocyte proliferation; positive regulation of G2/M transition of mitotic cell cycle; positive regulation of G2/MI transition of meiotic cell cycle; protein dephosphorylation; response to radiation
|
|
Reference #:
P48965
(UniProtKB)
|
|
Alt. Names/Synonyms: Cdc25a; cell division cycle 25 homolog A (S. pombe); cell division cycle 25A; Dual specificity phosphatase Cdc25A; M-phase inducer phosphatase 1; MPIP1
|
|
Gene Symbols: Cdc25a
|
|
Molecular weight:
59,218 Da
|
|
Basal Isoelectric point:
6.67
Predict pI for various phosphorylation states
|
|
CST Pathways:
G1/S Checkpoint
|
G2/M DNA Damage Checkpoint
|
