CDC25A Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly dephosphorylates CDK1 and stimulates its kinase activity. Also dephosphorylates CDK2 in complex with cyclin E, in vitro. Belongs to the MPI phosphatase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity
Chromosomal Location of rat Ortholog: 8q32
Cellular Component:  cytoplasm; nucleus
Molecular Function:  chaperone binding; phosphoprotein phosphatase activity; protein kinase binding; protein tyrosine phosphatase activity
Biological Process:  cell division; cellular response to UV; G1/S transition of mitotic cell cycle; G2/M transition of mitotic cell cycle; positive regulation of cell cycle G2/M phase transition; positive regulation of cholangiocyte proliferation; positive regulation of G2/M transition of mitotic cell cycle; positive regulation of G2/MI transition of meiotic cell cycle; protein dephosphorylation; response to radiation
Reference #:  P48965 (UniProtKB)
Alt. Names/Synonyms: Cdc25a; cell division cycle 25 homolog A (S. pombe); cell division cycle 25A; Dual specificity phosphatase Cdc25A; M-phase inducer phosphatase 1; MPIP1
Gene Symbols: Cdc25a
Molecular weight: 59,218 Da
Basal Isoelectric point: 6.67  Predict pI for various phosphorylation states
CST Pathways:  G1/S Checkpoint  |  G2/M DNA Damage Checkpoint
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene