CASP9 a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspase APAF1; this step is thought to be one of the earliest in the caspase activation cascade. Alternative splicing results in two isoforms. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; EC; Protease
Chromosomal Location of Human Ortholog: 5q36
Cellular Component:  apoptosome; cytoplasm; cytosol; mitochondrion; nucleus; protein-containing complex
Molecular Function:  cysteine-type endopeptidase activity; cysteine-type endopeptidase activity involved in apoptotic process; cysteine-type endopeptidase activity involved in apoptotic signaling pathway; cysteine-type peptidase activity; identical protein binding; peptidase activity; protein binding; protein kinase binding; SH3 domain binding
Biological Process:  activation of cysteine-type endopeptidase activity involved in apoptotic process; aging; apoptotic process; cellular response to dexamethasone stimulus; cellular response to DNA damage stimulus; cellular response to organic cyclic compound; cellular response to UV; glial cell apoptotic process; intrinsic apoptotic signaling pathway in response to DNA damage; kidney development; leukocyte apoptotic process; positive regulation of apoptotic process; positive regulation of neuron apoptotic process; proteolysis; regulation of response to DNA damage stimulus; response to antibiotic; response to auditory stimulus; response to cobalt ion; response to estradiol; response to ischemia; response to lipopolysaccharide; response to organic cyclic compound; response to UV; signal transduction in response to DNA damage
Reference #:  Q9JHK1 (UniProtKB)
Alt. Names/Synonyms: 25 kDa caspase-9 dominant negative protein; Apaf3; apoptotic protease activating factor 3; apoptotic protease Mch-6; Casp-9-CTD; Casp9; Casp9_v1; caspase 9, apoptosis-related cysteine peptidase; Caspase 9, isoform CRA_a; Caspase-9; caspase-9 dominant negative form; Caspase-9 long isoform; caspase-9-carboxyl-terminal divergent; Ice-Lap6; Ice-like apoptotic protease 6; Mch6; RNCASP9
Gene Symbols: Casp9
Molecular weight: 50,400 Da
Basal Isoelectric point: 6.04  Predict pI for various phosphorylation states
CST Pathways:  Alzheimer's Disease  |  Apoptosis Regulation  |  Death Receptor Signaling  |  ErbB/HER Signaling  |  Inhibition of Apoptosis  |  Mitochondrial Control of Apoptosis
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene