CASP9 Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9. Belongs to the peptidase C14A family. Ubiquitous, with highest expression in the heart, moderate expression in liver, skeletal muscle, and pancreas. Low levels in all other tissues. Within the heart, specifically expressed in myocytes. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; EC; Protease
Chromosomal Location of Human Ortholog: 5q36
Cellular Component:  apoptosome; cytoplasm; cytosol; mitochondrion; nucleus; protein-containing complex
Molecular Function:  cysteine-type endopeptidase activity; cysteine-type endopeptidase activity involved in apoptotic process; cysteine-type endopeptidase activity involved in apoptotic signaling pathway; cysteine-type peptidase activity; identical protein binding; peptidase activity; protein binding; protein kinase binding; SH3 domain binding
Biological Process:  activation of cysteine-type endopeptidase activity involved in apoptotic process; aging; apoptotic process; cellular response to dexamethasone stimulus; cellular response to DNA damage stimulus; cellular response to organic cyclic compound; cellular response to UV; glial cell apoptotic process; intrinsic apoptotic signaling pathway in response to DNA damage; kidney development; leukocyte apoptotic process; positive regulation of apoptotic process; positive regulation of neuron apoptotic process; proteolysis; regulation of response to DNA damage stimulus; response to antibiotic; response to auditory stimulus; response to cobalt ion; response to estradiol; response to ischemia; response to lipopolysaccharide; response to organic cyclic compound; response to UV; signal transduction in response to DNA damage
Reference #:  Q9JHK1 (UniProtKB)
Alt. Names/Synonyms: 25 kDa caspase-9 dominant negative protein; Apaf3; apoptotic protease activating factor 3; apoptotic protease Mch-6; Casp-9-CTD; Casp9; Casp9_v1; caspase 9, apoptosis-related cysteine peptidase; Caspase 9, isoform CRA_a; Caspase-9; caspase-9 dominant negative form; Caspase-9 long isoform; caspase-9-carboxyl-terminal divergent; Ice-Lap6; Ice-like apoptotic protease 6; Mch6; RNCASP9
Gene Symbols: Casp9
Molecular weight: 50,400 Da
Basal Isoelectric point: 6.04  Predict pI for various phosphorylation states
CST Pathways:  Alzheimer's Disease  |  Apoptosis Regulation  |  Death Receptor Signaling  |  ErbB/HER Signaling  |  Inhibition of Apoptosis  |  Mitochondrial Control of Apoptosis
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene