hnRNP D0 Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Also binds to double- and single-stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5'-UUAG-3' sequence and also weaker to the single-stranded 5'-TTAGGG-3' telomeric DNA repeat. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. May play a role in the regulation of the rhythmic expression of circadian clock core genes. Directly binds to the 3'UTR of CRY1 mRNA and induces CRY1 rhythmic translation. May also be involved in the regulation of PER2 translation. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA splicing; RNA-binding
Chromosomal Location of Human Ortholog: 5|5 E4
Cellular Component:  cytoplasm; cytosol; nucleoplasm; nucleus; ribonucleoprotein complex; synapse
Molecular Function:  AT DNA binding; chromatin binding; DNA binding; histone deacetylase binding; mRNA 3'-UTR AU-rich region binding; mRNA binding; nucleic acid binding; protein binding; RNA binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding; telomeric DNA binding; transcription factor binding
Biological Process:  3'-UTR-mediated mRNA destabilization; cellular response to nitric oxide; cellular response to putrescine; circadian regulation of translation; mRNA stabilization; mRNA transcription by RNA polymerase II; negative regulation of gene expression; positive regulation of gene expression; positive regulation of telomerase RNA reverse transcriptase activity; positive regulation of telomere capping; positive regulation of translation; regulation of circadian rhythm; regulation of mRNA stability; regulation of telomere maintenance; response to calcium ion; response to rapamycin; response to sodium phosphate; rhythmic process
Reference #:  Q60668 (UniProtKB)
Alt. Names/Synonyms: AU-rich element RNA-binding protein 1; Auf; Auf1; C230004L04; heterogeneous nuclear ribonucleoprotein D; Heterogeneous nuclear ribonucleoprotein D0; hnRNP D0; Hnrnpd; Hnrpd
Gene Symbols: Hnrnpd
Molecular weight: 38,354 Da
Basal Isoelectric point: 7.61  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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hnRNP D0

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene