hnRNP D0 a ubiquitously expressed heterogeneous nuclear ribonucleoprotein (hnRNP). Implicated in the regulation of mRNA stability. Has two repeats of quasi-RRM domains that bind to RNAs. It localizes to both the nucleus and the cytoplasm. Four alternatively spliced transcript variants have been described. Note: This description may include information from UniProtKB.
Protein type: RNA splicing; RNA-binding
Chromosomal Location of Human Ortholog: 5|5 E4
Cellular Component:  cytoplasm; cytosol; nucleoplasm; nucleus; ribonucleoprotein complex; synapse
Molecular Function:  AT DNA binding; chromatin binding; DNA binding; histone deacetylase binding; mRNA 3'-UTR AU-rich region binding; mRNA binding; nucleic acid binding; protein binding; RNA binding; sequence-specific DNA binding; sequence-specific double-stranded DNA binding; telomeric DNA binding; transcription factor binding
Biological Process:  3'-UTR-mediated mRNA destabilization; cellular response to nitric oxide; cellular response to putrescine; circadian regulation of translation; mRNA stabilization; mRNA transcription by RNA polymerase II; negative regulation of gene expression; positive regulation of gene expression; positive regulation of telomerase RNA reverse transcriptase activity; positive regulation of telomere capping; positive regulation of translation; regulation of circadian rhythm; regulation of mRNA stability; regulation of telomere maintenance; response to calcium ion; response to rapamycin; response to sodium phosphate; rhythmic process
Reference #:  Q60668 (UniProtKB)
Alt. Names/Synonyms: AU-rich element RNA-binding protein 1; Auf1; C230004L04; heterogeneous nuclear ribonucleoprotein D; Heterogeneous nuclear ribonucleoprotein D0; hnRNP D0; Hnrnpd; Hnrpd
Gene Symbols: Hnrnpd
Molecular weight: 38,354 Da
Basal Isoelectric point: 7.61  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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hnRNP D0

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene