APC5 Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Belongs to the APC5 family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Ubiquitin conjugating system
Chromosomal Location of mouse Ortholog: 5|5 F
Cellular Component:  anaphase-promoting complex; cytoplasm; cytoskeleton; nucleus; spindle
Molecular Function:  protein phosphatase binding
Biological Process:  anaphase-promoting complex-dependent catabolic process; cell cycle; cell division; positive regulation of mitotic metaphase/anaphase transition; protein K11-linked ubiquitination
Reference #:  Q8BTZ4 (UniProtKB)
Alt. Names/Synonyms: 2510006G12Rik; AA408751; AA536819; AA986414; Anapc5; Anaphase-promoting complex subunit 5; Anpc5; APC5; Cyclosome subunit 5
Gene Symbols: Anapc5
Molecular weight: 83,098 Da
Basal Isoelectric point: 6.24  Predict pI for various phosphorylation states
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APC5

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene