MRLC2 non-sarcomeric myosin regulatory light chain 2. Binds calcium and plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity. Phosphorylation of MLC-2 in the presence of calcium and calmodulin increases the actin-activated myosin ATPase activity and thereby regulates the contractile activity. Myosin is an hexamer of 2 heavy chains and 4 light chains. Note: This description may include information from UniProtKB.
Protein type: Contractile
Chromosomal Location of Human Ortholog: 9q38
Cellular Component:  apical part of cell; cell cortex region; myosin complex; myosin II complex; protein-containing complex; stress fiber; Z disc
Molecular Function:  calcium ion binding; myosin heavy chain binding
Biological Process:  regulation of cell shape
Reference #:  P18666 (UniProtKB)
Alt. Names/Synonyms: MLC-2; MLC20; Mrlc2; Myl12b; Mylc2b; Myosin regulatory light chain 12B; Myosin regulatory light chain 2-B, smooth muscle isoform; Myosin regulatory light chain 20 kDa; Myosin regulatory light chain MRLC2; Myosin RLC-B; myosin, light chain 12B, regulatory
Gene Symbols: Myl12b
Molecular weight: 19,838 Da
Basal Isoelectric point: 4.78  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  TGF-ß Signaling
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MRLC2

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein