HSD3B2 3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. Belongs to the 3-beta-HSD family. Expressed in adrenal gland, testis and ovary. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; EC; Endoplasmic reticulum; Isomerase; Lipid Metabolism - C21-steroid hormone; Lipid Metabolism - androgen and estrogen; Membrane protein, integral; Mitochondrial; Oxidoreductase
Chromosomal Location of Human Ortholog: 3 F2.2|3 42.85 cM
Cellular Component:  endoplasmic reticulum; integral component of membrane; intracellular membrane-bounded organelle; membrane; mitochondrial inner membrane; mitochondrial intermembrane space; mitochondrion
Molecular Function:  3-beta-hydroxy-delta5-steroid dehydrogenase activity; catalytic activity; isomerase activity; oxidoreductase activity; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; steroid delta-isomerase activity
Biological Process:  C21-steroid hormone metabolic process; hippocampus development; metabolic process; response to corticosterone; steroid biosynthetic process
Reference #:  P26149 (UniProtKB)
Alt. Names/Synonyms: 3 beta-hydroxysteroid dehydrogenase 2; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II; 3-beta-HSD II; 3-beta-hydroxy-5-ene steroid dehydrogenase; 3-beta-hydroxy-Delta(5)-steroid dehydrogenase; 3BHS2; Delta-5-3-ketosteroid isomerase; Hsd3b2; hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2; hydroxysteroid dehydrogenase-2, delta<5>-3-beta; OTTMUSP00000007145; OTTMUSP00000007146; Progesterone reductase; Steroid Delta-isomerase
Gene Symbols: Hsd3b2
Molecular weight: 41,923 Da
Basal Isoelectric point: 5.95  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein