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HSD3B2
3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. Belongs to the 3-beta-HSD family. Expressed in adrenal gland, testis and ovary. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 1.1.1.145; EC 5.3.3.1; Endoplasmic reticulum; Isomerase; Lipid Metabolism - C21-steroid hormone; Lipid Metabolism - androgen and estrogen; Membrane protein, integral; Mitochondrial; Oxidoreductase |
| Chromosomal Location of mouse Ortholog: 3 F2.2|3 42.85 cM |
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Cellular Component:
cytoplasm; endoplasmic reticulum; intercellular bridge; intracellular membrane-bounded organelle; membrane; mitochondrial inner membrane; mitochondrial intermembrane space; mitochondrion; nucleolus
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Molecular Function:
3-beta-hydroxy-delta5-steroid dehydrogenase activity; catalytic activity; cholesterol dehydrogenase activity; isomerase activity; oxidoreductase activity; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; steroid delta-isomerase activity
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Biological Process:
androgen biosynthetic process; C21-steroid hormone biosynthetic process; C21-steroid hormone metabolic process; hippocampus development; lipid metabolic process; metabolic process; negative regulation of iron ion transport; response to corticosterone; steroid biosynthetic process
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Reference #:
P26149
(UniProtKB)
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Alt. Names/Synonyms: 3 beta-hydroxysteroid dehydrogenase 2; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II; 3-beta-HSD II; 3-beta-hydroxy-5-ene steroid dehydrogenase; 3-beta-hydroxy-Delta(5)-steroid dehydrogenase; 3BHS2; Delta-5-3-ketosteroid isomerase; Hsd3b2; hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2; hydroxysteroid dehydrogenase-2, delta<5>-3-beta; OTTMUSP00000007145; OTTMUSP00000007146; Progesterone reductase; Steroid Delta-isomerase
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Gene Symbols: Hsd3b2
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Molecular weight:
41,923 Da
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Basal Isoelectric point:
5.95
Predict pI for various phosphorylation states
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