ENSA iso3 Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-67 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. Also acts as a stimulator of insulin secretion by interacting with sulfonylurea receptor (ABCC8), thereby preventing sulfonylurea from binding to its receptor and reducing K(ATP) channel currents. Belongs to the endosulfine family. Widely expressed with high levels in skeletal muscle and brain and lower levels in the pancreas. 9 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Inhibitor; Protein phosphatase, regulatory subunit
Chromosomal Location of Human Ortholog: 1q21.3
Cellular Component:  nucleoplasm
Molecular Function:  ion channel inhibitor activity; phosphatase inhibitor activity; potassium channel inhibitor activity; protein binding; protein phosphatase 2A binding; protein phosphatase regulator activity; signaling receptor binding
Biological Process:  cell division; G2/M transition of mitotic cell cycle; mitotic cell cycle; negative regulation of phosphoprotein phosphatase activity; regulation of insulin secretion; response to glucose; response to nutrient
Reference #:  O43768-3 (UniProtKB)
Alt. Names/Synonyms: Alpha-endosulfine; ARPP-19e; endosulfine alpha; ENSA; ENSA iso3
Gene Symbols: ENSA
Molecular weight: 15,281 Da
Basal Isoelectric point: 5.79  Predict pI for various phosphorylation states
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ENSA iso3

Protein Structure Not Found.

Cross-references to other databases:  cBioPortal  |  Wikipedia  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein