| GluR3 Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIA3 subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB. |
| Protein type: Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass |
| Chromosomal Location of rat Ortholog: Xq35 |
| Cellular Component: AMPA glutamate receptor complex; asymmetric synapse; dendrite; dendritic shaft; dendritic spine; glutamatergic synapse; ionotropic glutamate receptor complex; membrane; neuronal cell body; parallel fiber to Purkinje cell synapse; perikaryon; plasma membrane; postsynaptic density; postsynaptic density membrane; postsynaptic membrane; presynaptic active zone membrane; presynaptic membrane; protein-containing complex; synaptic cleft; terminal bouton |
| Molecular Function: AMPA glutamate receptor activity; amyloid-beta binding; ionotropic glutamate receptor activity; ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential; protein binding; transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential |
| Biological Process: chemical synaptic transmission; chemical synaptic transmission, postsynaptic; ionotropic glutamate receptor signaling pathway; modulation of chemical synaptic transmission; monoatomic ion transmembrane transport; regulation of postsynaptic membrane potential; regulation of presynaptic membrane potential; regulation of receptor recycling; response to fungicide; response to lithium ion; synaptic transmission, glutamatergic |
| Reference #: P19492 (UniProtKB) |
| Alt. Names/Synonyms: AMPA-selective glutamate receptor 3; GluR-3; GluR-C; GluR-K3; Glur3; Glutamate receptor 3; Glutamate receptor ionotropic, AMPA 3; glutamate receptor, ionotrophic, AMPA 3; glutamate receptor, ionotropic, AMPA3 (alpha 3); Gria3 |
| Gene Symbols: Gria3 |
| Molecular weight: 100,373 Da |
| Basal Isoelectric point: 8.38 Predict pI for various phosphorylation states |
| CST Pathways: Alzheimer's Disease | Parkinson's Disease |
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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GluR3 |
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Cross-references to other databases:
AlphaFold
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STRING
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Reactome
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BioGPS
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Pfam
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