CUL5 Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. May form a cell surface vasopressin receptor. Belongs to the cullin family. Note: This description may include information from UniProtKB.
Protein type: Ubiquitin conjugating system
Chromosomal Location of rat Ortholog: 8q24
Cellular Component:  Cul5-RING ubiquitin ligase complex; cullin-RING ubiquitin ligase complex; cytoplasm; nucleus; plasma membrane; SCF ubiquitin ligase complex
Molecular Function:  protein heterodimerization activity; ubiquitin protein ligase binding; ubiquitin-protein transferase activity; vasopressin receptor activity
Biological Process:  cerebral cortex radially oriented cell migration; G protein-coupled receptor signaling pathway; proteasome-mediated ubiquitin-dependent protein catabolic process; protein polyubiquitination; protein ubiquitination; radial glia guided migration of Purkinje cell; regulation of cytosolic calcium ion concentration; response to osmotic stress; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; ubiquitin-dependent protein catabolic process
Reference #:  Q9JJ31 (UniProtKB)
Alt. Names/Synonyms: CUL-5; Cul5; cullin 5; Cullin-5; VACM-1; Vacm1; Vasopressin-activated calcium-mobilizing receptor 1; vasopressin-activated calcium-mobilizing receptor protein
Gene Symbols: Cul5
Molecular weight: 90,890 Da
Basal Isoelectric point: 8.08  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene