PIK3R2 Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Indirectly regulates autophagy. Promotes nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement. Belongs to the PI3K p85 subunit family. Note: This description may include information from UniProtKB.
Protein type: Kinase, lipid; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 16p14
Cellular Component:  cytosol; focal adhesion; nucleus; phosphatidylinositol 3-kinase complex
Molecular Function:  1-phosphatidylinositol-3-kinase regulator activity; kinase activity; phosphatidylinositol 3-kinase regulator activity; phosphatidylinositol 3-kinase regulatory subunit binding; phosphotyrosine residue binding; protein heterodimerization activity; protein phosphatase binding; receptor tyrosine kinase binding; transcription factor binding
Biological Process:  cellular glucose homeostasis; cellular response to insulin stimulus; insulin receptor signaling pathway; negative regulation of cell migration involved in sprouting angiogenesis; negative regulation of MAPK cascade; phosphatidylinositol 3-kinase signaling; phosphatidylinositol phosphorylation; phosphorylation; positive regulation of cell adhesion; positive regulation of protein import into nucleus; positive regulation of transcription by RNA polymerase II; protein transport; regulation of actin filament polymerization; regulation of autophagy; regulation of phosphatidylinositol 3-kinase activity; regulation of protein localization to plasma membrane; regulation of stress fiber assembly; response to endoplasmic reticulum stress
Reference #:  Q63788 (UniProtKB)
Alt. Names/Synonyms: MGC108697; P85B; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta; phosphatidylinositol 3-kinase regulartory subunit polypeptide 2; Phosphatidylinositol 3-kinase regulatory subunit beta; phosphatidylinositol 3-kinase, regulartory subunit, polypeptide 2; phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta); phosphoinositide-3-kinase, regulatory subunit 2 (beta); PI3-kinase p85 subunit beta; PI3-kinase regulatory subunit beta; PI3-kinase subunit p85-beta; PI3K regulatory subunit beta; Pik3r2; ptdIns-3-kinase p85-beta; PtdIns-3-kinase regulatory subunit beta; PtdIns-3-kinase regulatory subunit p85-beta
Gene Symbols: Pik3r2
Molecular weight: 81,329 Da
Basal Isoelectric point: 5.79  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Adherens Junction Dynamics  |  AMPK Signaling  |  Angiogenesis  |  Apoptosis Regulation  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  ESC Pluripotency and Differentiation  |  Growth And Differentiation Control by MAPKs  |  IL6 Signaling  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  Microtubule Dynamics  |  Mitochondrial Control of Apoptosis  |  mTOR Signaling  |  NF-kB Signaling  |  PI3K/Akt Signaling  |  Protein Kinase C Signaling  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling  |  TGF-ß Signaling  |  Translation: eIF4E and p70S6K  |  Warburg Effect
Select Structure to View Below

PIK3R2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene