EEF1A1 an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas. Promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Note: This description may include information from UniProtKB.
Protein type: Nucleolus; Translation; Translation elongation
Chromosomal Location of Human Ortholog: 9|9 E1
Cellular Component:  cortical actin cytoskeleton; cytoplasm; cytosol; membrane; nucleolus; nucleus; plasma membrane; ruffle membrane
Molecular Function:  calmodulin binding; drug binding; GTP binding; GTPase activity; kinase binding; mRNA binding; nucleotide binding; protein binding; protein kinase binding; translation elongation factor activity; tRNA binding
Biological Process:  cellular response to epidermal growth factor stimulus; negative regulation of reactive oxygen species biosynthetic process; positive regulation of cell death; positive regulation of neuron projection development; protein homooligomerization; regulation of D-erythro-sphingosine kinase activity; translation; translational elongation
Reference #:  P10126 (UniProtKB)
Alt. Names/Synonyms: Eef1a; eEF1A-1; Eef1a1; Eef1a1-ps1; EF-1-alpha-1; EF-Tu; EF1A1; Elongation factor 1-alpha 1; Elongation factor Tu; Eukaryotic elongation factor 1 A-1; eukaryotic translation elongation factor 1 alpha 1
Gene Symbols: Eef1a1
Molecular weight: 50,114 Da
Basal Isoelectric point: 9.1  Predict pI for various phosphorylation states
CST Pathways:  Translational Control
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  Ensembl Protein