ZO1 TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton. The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells. Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling. With TJP2 and TJP3, participates to the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus. Belongs to the MAGUK family. The alpha-containing isoform is found in most epithelial cell junctions. The short isoform is found both in endothelial cells and the highly specialized epithelial junctions of renal glomeruli and Sertoli cells of the seminiferous tubules. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis
Chromosomal Location of mouse Ortholog: 7 C|7 35.02 cM
Cellular Component:  adherens junction; apical junction complex; apical part of cell; apical plasma membrane; apicolateral plasma membrane; basolateral plasma membrane; bicellular tight junction; cell junction; cell surface; cell-cell adherens junction; cell-cell junction; cytoplasm; cytosol; gap junction; intercalated disc; intercellular canaliculus; membrane; nucleus; plasma membrane; protein-containing complex; tight junction
Molecular Function:  calmodulin binding; connexin binding; protein binding; protein C-terminus binding; protein domain specific binding
Biological Process:  blastocyst formation; establishment of endothelial intestinal barrier; sensory perception of sound
Reference #:  P39447 (UniProtKB)
Alt. Names/Synonyms: OTTMUSP00000017707; Tight junction protein 1; Tight junction protein ZO-1; Tjp1; ZO-; Zo1; Zona occludens protein 1; Zonula occludens protein 1
Gene Symbols: Tjp1
Molecular weight: 194,742 Da
Basal Isoelectric point: 6.18  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein